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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(HBV-HCV)Kko
transgene insertion, Kazuhiko Koike
MGI:3794557
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(HBV-HCV)Kko/0 C57BL/6N-Tg(HBV-HCV)Kko MGI:5578176


Genotype
MGI:5578176
tg1
Allelic
Composition
Tg(HBV-HCV)Kko/0
Genetic
Background
C57BL/6N-Tg(HBV-HCV)Kko
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• disappearance of the double structure of mitochondrial membranes in the liver (J:52686)
• disruption of the double structure of the mitochondrial membrane from liver mitochondria (J:69727)
• intracellular increase in lipid peroxidization in the liver as showed by an increase in hydroperoxide products indicating oxidative stress in the liver in the absence of inflammation

liver/biliary system
• hepatocytes from 12 month or older mice exhibit scattered residual bodies or lipofuscin granules and secondary lysosomes carrying various cytoplasmic organelles, indicating signs of damage induced by reactive oxygen species
• mild steatosis at young age that becomes moderate to severe with increasing age (J:52686)
• all males and about 50% of females develop steatosis by 6 months of age (J:52686)
• however, mice show normal weight and total cholesterol and triglyceride levels (J:52686)
• hepatocellular carcinoma develops from within the adenomas without cytoplasmic fat droplets
• male mice develop hepatic tumors after 16 months of age that first appear as adenomas containing fat droplets in the cytoplasm
• intracellular increase in lipid peroxidization in the liver as indicated by an increase in hydroperoxide products by about 170% compared to controls
• administration of alcohol causes an increase in the levels of hydroperoxides of phosphatidylcholine

neoplasm
• hepatocellular carcinoma develops from within the adenomas without cytoplasmic fat droplets
• male mice develop hepatic tumors after 16 months of age that first appear as adenomas containing fat droplets in the cytoplasm

homeostasis/metabolism
• total and reduced glutathione level is lower than in controls
• males show an increase in catalase activity in the liver

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:69727





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory