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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lactb2Tg(Igh-Meis1)2770Amb
transgene insertion 2770, Arthur M Buchberg
MGI:3793472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lactb2Tg(Igh-Meis1)2770Amb/Lactb2Tg(Igh-Meis1)2770Amb FVB/NJ-Lactb2Tg(Igh-Meis1)2770Amb MGI:3795904
cx2
ArTfm/Ar+
Lactb2Tg(Igh-Meis1)2770Amb/Lactb2Tg(Igh-Meis1)2770Amb
involves: FVB/NJ MGI:3795905


Genotype
MGI:3795904
hm1
Allelic
Composition
Lactb2Tg(Igh-Meis1)2770Amb/Lactb2Tg(Igh-Meis1)2770Amb
Genetic
Background
FVB/NJ-Lactb2Tg(Igh-Meis1)2770Amb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lactb2Tg(Igh-Meis1)2770Amb mutation (0 available); any Lactb2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean male death occurs at 40 days with signs of distress appearing 12 to 24 hours prior to death
• lethality is not background dependent and is observed in mice crossed to Mus castaneus, C57BL/6J and BXH2

reproductive system
N
• male mice that survive long enough to reproduce are fertile
• moribund male mice exhibit underdeveloped seminal vesicles

liver/biliary system
• moribund male mice exhibit slightly enlarged livers unlike in wild-type mice
• moribund male mice exhibit microvesicular steatosis unlike in wild-type mice
• moribund male mice exhibit salmon-colored liver with small, pale granules dispersed throughout the organ unlike in wild-type mice

respiratory system
• in male mice just prior to death

growth/size/body
• peripubescent male mice are smaller than normal

adipose tissue
• moribund male mice exhibit underdeveloped fat pads surrounding the seminal vesicles

behavior/neurological
• just prior to death, male mice exhibit extreme lethargy unlike in wild-type mice

cardiovascular system
• just prior to death, male mice exhibit prominent blood vasculature of the extremities unlike in wild-type mice

endocrine/exocrine glands
• moribund male mice exhibit underdeveloped seminal vesicles

integument
• just prior to death, male mice exhibit scruffy fur unlike in wild-type mice
• just prior to death, male mice exhibit pinkish or purplish skin color unlike in wild-type mice




Genotype
MGI:3795905
cx2
Allelic
Composition
ArTfm/Ar+
Lactb2Tg(Igh-Meis1)2770Amb/Lactb2Tg(Igh-Meis1)2770Amb
Genetic
Background
involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (3 available); any Ar mutation (17 available)
Lactb2Tg(Igh-Meis1)2770Amb mutation (0 available); any Lactb2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive at least 200 days unlike Lactb2Tg(Igh-Meis1)2770Amb homozygotes





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory