Mouse Genome Informatics
hm1
    Lactb2Tg(Igh-Meis1)2770Amb/Lactb2Tg(Igh-Meis1)2770Amb
FVB/NJ-Lactb2Tg(Igh-Meis1)2770Amb
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mean male death occurs at 40 days with signs of distress appearing 12 to 24 hours prior to death
• lethality is not background dependent and is observed in mice crossed to Mus castaneus, C57BL/6J and BXH2

reproductive system
N
• male mice that survive long enough to reproduce are fertile (J:79618)
• moribund male mice exhibit underdeveloped seminal vesicles (J:79618)

liver/biliary system
• moribund male mice exhibit slightly enlarged livers unlike in wild-type mice
• moribund male mice exhibit microvesicular steatosis unlike in wild-type mice
• moribund male mice exhibit salmon-colored liver with small, pale granules dispersed throughout the organ unlike in wild-type mice

respiratory system
• in male mice just prior to death

growth/size
• peripubescent male mice are smaller than normal

adipose tissue
• moribund male mice exhibit underdeveloped fat pads surrounding the seminal vesicles

behavior/neurological
• just prior to death, male mice exhibit extreme lethargy unlike in wild-type mice

cardiovascular system
• just prior to death, male mice exhibit prominent blood vasculature of the extremities unlike in wild-type mice

endocrine/exocrine glands
• moribund male mice exhibit underdeveloped seminal vesicles (J:79618)

integument
• just prior to death, male mice exhibit scruffy fur unlike in wild-type mice
• just prior to death, male mice exhibit pinkish or purplish skin color unlike in wild-type mice


Mouse Genome Informatics
cx2
    ArTfm/Ar+
Lactb2Tg(Igh-Meis1)2770Amb/Lactb2Tg(Igh-Meis1)2770Amb

involves: FVB/NJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• mice survive at least 200 days unlike Lactb2Tg(Igh-Meis1)2770Amb homozygotes (J:79618)