About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcc2tm1Dgen
targeted mutation 1, Deltagen
MGI:3790671
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abcc2tm1Dgen/Abcc2tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3804924


Genotype
MGI:3804924
hm1
Allelic
Composition
Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc2tm1Dgen mutation (0 available); any Abcc2 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• total bilirubin levels were 5-fold higher in mutant mice
• 60% of total bilirubin was conjugated bilirubin, where as the level of conjugated bilirubin in serum of wild-type mice was undetectable
• level of direct bilirubin were 6.7-fold higher in mutant mice urine
• 1.5-fold higher in male mutant mice, but no significant changes was observed between female mutant mice and control mice
• a slightly decreased alkaline phosphatase level

liver/biliary system
• decreased biliary secretion of dibromosulfphthalein administered intravenously
• the biliary excretion rate of glutathione was 16-fold lower in mutant mice
• the biliary excretion rate of bilirubin glucuronides was 2-fold lower in mutant mice
• a 3-fold increase in glutathione level in mutant liver extracts





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory