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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-ESR1/Disc1*)2698.1Sva
transgene insertion 2698.1, Alcino J Silva
MGI:3785794
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0 involves: C57BL/6 * C57BL/6NTac MGI:3785829


Genotype
MGI:3785829
tg1
Allelic
Composition
Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0
Genetic
Background
involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-ESR1/Disc1*)2698.1Sva mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• adult mice injected with tamoxifen at P7 show deficits in spatial working memory in a working memory test (delayed nonmatched to place task, DNMTP) compared to adult controls (wild-type and vehicle-treated transgenic animals)
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult wild-type
• in forced-swim test, adult mice treated with tamoxifen at P7 display depressive-like behavior as demonstrated by shorter latencies between floating episodes than those of control mice
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult controls
• in a social choice paradigm, adult mice treated with tamoxifen at P7 spend significantly more time in empty chamber away from stimulus mouse than in stimulus mouse chamber compared to controls
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult controls

nervous system
• reduced dendritic complexity in adult mice treated with tamoxifen at P7
• numbers of branch points and intersections in hippocampal neurons in adult mice treated with tamoxifen at P7 are reduced compared to controls;
• adult mice treated with tamoxifen at P7 show reduced hippocampal synaptic input/output function compared to controls
• paired pulse facilitation and long term potentiation in mice treated at P7 are both normal indicating that presynaptic function and LTP are unaffected by transgenic protein expression

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:127235





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory