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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-ESR1/Disc1*)2698.1Sva
transgene insertion 2698.1, Alcino J Silva
MGI:3785794
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0 involves: C57BL/6 * C57BL/6NTac MGI:3785829


Genotype
MGI:3785829
tg1
Allelic
Composition
Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0
Genetic
Background
involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-ESR1/Disc1*)2698.1Sva mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• adult mice injected with tamoxifen at P7 show deficits in spatial working memory in a working memory test (delayed nonmatched to place task, DNMTP) compared to adult controls (wild-type and vehicle-treated transgenic animals)
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult wild-type
• in forced-swim test, adult mice treated with tamoxifen at P7 display depressive-like behavior as demonstrated by shorter latencies between floating episodes than those of control mice
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult controls
• in a social choice paradigm, adult mice treated with tamoxifen at P7 spend significantly more time in empty chamber away from stimulus mouse than in stimulus mouse chamber compared to controls
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult controls

nervous system
• reduced dendritic complexity in adult mice treated with tamoxifen at P7
• numbers of branch points and intersections in hippocampal neurons in adult mice treated with tamoxifen at P7 are reduced compared to controls;
• adult mice treated with tamoxifen at P7 show reduced hippocampal synaptic input/output function compared to controls
• paired pulse facilitation and long term potentiation in mice treated at P7 are both normal indicating that presynaptic function and LTP are unaffected by transgenic protein expression





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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory