Phenotypes associated with this allele

• Allele Symbol: Cdh13^tm1Brns
• Allele Name: targeted mutation 1, Barbara Ranscht
• Allele ID: MGI:3778287
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh13^tm1Brns/Cdh13^tm1Brns	involves: 129	MGI:3809816
cx2	Cdh13^tm1Brns/Cdh13^tm1Brns Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6 * FVB/N	MGI:3809817

Genotype
MGI:3809816

hm1

• Allelic Composition: Cdh13^tm1Brns/Cdh13^tm1Brns
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

retina neovascularization ( J:132759 )

• hypoxia-induced retinal vasculature exhibits a 63% reduction in vascular glomeruli and a 53% reduction in vessel branching compared to in wild-type mice

homeostasis/metabolism

increased circulating adiponectin level ( J:132759 )

• serum adiponectin levels are increased compared to in wild-type mice

reproductive system

reproductive system phenotype ( J:132759 )

N • mammary gland development and function are normal

neoplasm

neoplasm ( J:132759 )

N • mice exhibit no spontaneous tumor formation

vision/eye

retina neovascularization ( J:132759 )

• hypoxia-induced retinal vasculature exhibits a 63% reduction in vascular glomeruli and a 53% reduction in vessel branching compared to in wild-type mice

Genotype
MGI:3809817

cx2

• Allelic Composition: Cdh13^tm1Brns/Cdh13^tm1Brns; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6 * FVB/N

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:132759 )

• unlike in wild-type mice or Cdh13^tm1Brns homozygotes

mortality/aging

mortality/aging ( J:132759 )

N • mice exhibit an 18.5 day increase in average survival time compared to in Tg(MMTV-PyVT)634Mul mice

neoplasm

abnormal tumor vascularization ( J:132759 )

• tumors exhibit decreased neovscularization compared to in Tg(MMTV-PyVT)634Mul mice

increased mammary gland tumor incidence ( J:132759 )

• unlike in wild-type mice or Cdh13^tm1Brns homozygotes

increased metastatic potential ( J:132759 )

• all tumors exhibit pulmonary metastases unlike in Tg(MMTV-PyVT)634Mul mice

abnormal tumor morphology ( J:132759 )

• tumor endothelial cell density is reduced 31% and vessel branching is reduced 45% compared to in Tg(MMTV-PyVT)634Mul mice

• tumors exhibit a 6-fold increase in apoptosis and a 3-fold increase in oxygen-deprived areas compared to in Tg(MMTV-PyVT)634Mul mice

• tumors exhibit decreased neovscularization compared to in Tg(MMTV-PyVT)634Mul mice

• tumor incidence, diversity and differentiation are reduced compared to in Tg(MMTV-PyVT)634Mul mice

• when mice were transplanted with Tg(MMTV-PyVT)634Mul mice or Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul tumors, the weight of the tumors is reduced compared to when they are transplanted into wild-type mice

• adiponectin staining of tumors is reduced compared to in Tg(MMTV-PyVT)634Mul mice

• tumor proliferation is the same as in Tg(MMTV-PyVT)634Mul mice

decreased tumor growth/size ( J:132759 )

• mice exhibit a 3-fold reduction in the area covered by mammary tumors compared to in Tg(MMTV-PyVT)634Mul mice

decreased incidence of induced tumors ( J:132759 )

• mice exhibit a 10 day delay in mammary tumor onset, a 3-fold reduction in the area covered by mammary tumors and an 18.5 day increase in average survival time compared to in Tg(MMTV-PyVT)634Mul mice

integument

increased mammary gland tumor incidence ( J:132759 )

• unlike in wild-type mice or Cdh13^tm1Brns homozygotes

cardiovascular system

abnormal tumor vascularization ( J:132759 )

• tumors exhibit decreased neovscularization compared to in Tg(MMTV-PyVT)634Mul mice