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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac6tm1.1Pmt
targeted mutation 1.1, Patrick Matthias
MGI:3776868
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hdac6tm1.1Pmt/Hdac6tm1.1Pmt involves: 129P2/OlaHsd MGI:5708043
hm2
 		Hdac6tm1.1Pmt/Hdac6tm1.1Pmt involves: 129P2/OlaHsd * C57BL/6 MGI:3810640
cx3
 		Hdac6tm1.1Pmt/Y
Tg(SOD1*G93A)1Gur/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL MGI:5499285
ot4
 		Hdac6tm1.1Pmt/Y involves: 129P2/OlaHsd * C57BL/6 MGI:5499210


Genotype
MGI:5708043
hm1
Allelic
Composition		 Hdac6tm1.1Pmt/Hdac6tm1.1Pmt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation (0 available); any Hdac6 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-10 secretion ( J:228570 )
• from peritoneal elicited macrophages (PEM) and dendritic cells in response to LPS

homeostasis/metabolism




Genotype
MGI:3810640
hm2
Allelic
Composition		 Hdac6tm1.1Pmt/Hdac6tm1.1Pmt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation (0 available); any Hdac6 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:132629 )
N
• mice are fertile and exhibit normal fertilization

immune system
immune system phenotype ( J:132629 )
N
• despite modest effects to immune response, mice exhibit normal lymphocyte develpment
decreased IgG level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
decreased IgM level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice

skeleton
increased bone mineral content ( J:132629 )
• tibial bone mineral content is slightly increased at 3 months compared to wild-type mice
increased bone mineral density ( J:132629 )
• cancellous bone mineral density is moderately increased compared to wild-type mice
• however, after 3 months bone mineral density is normal

growth/size/body
increased body weight ( J:132629 )
• at 3 months

nervous system
nervous system phenotype ( J:132629 )
N
• mice exhibit normal brain and spinal cord morphology

hematopoietic system
decreased IgG level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
decreased IgM level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice




Genotype
MGI:5499285
cx3
Allelic
Composition		 Hdac6tm1.1Pmt/Y
Tg(SOD1*G93A)1Gur/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation (0 available); any Hdac6 mutation (14 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
abnormal survival ( J:194977 )
• modest increase in survival compared with Tg(SOD1*G93A)1Gur mice

nervous system
abnormal innervation pattern to muscle ( J:194977 )
• NMJ innervation of the gastrocnemius muscle is improved compared to in Tg(SOD1*G93A)1Gur mice
increased neuron number ( J:194977 )
• in the ventral horn compared to in Tg(SOD1*G93A)1Gur mice with more pronounced protection of large neurons
abnormal action potential ( J:194977 )
• mice exhibit higher compound action potential amplitudes compared with Tg(SOD1*G93A)1Gur mice

behavior/neurological
decreased grip strength ( J:194977 )
• same age of onset as in Tg(SOD1*G93A)1Gur mice




Genotype
MGI:5499210
ot4
Allelic
Composition		 Hdac6tm1.1Pmt/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation (0 available); any Hdac6 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:132629 )
N
• mice are fertile and exhibit normal fertilization

immune system
immune system phenotype ( J:132629 )
N
• despite modest effects to immune response, mice exhibit normal lymphocyte develpment
decreased IgG level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
decreased IgM level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice

skeleton
increased bone mineral content ( J:132629 )
• tibial bone mineral content is slightly increased at 3 months compared to wild-type mice
increased bone mineral density ( J:132629 )
• cancellous bone mineral density is moderately increased compared to wild-type mice
• however, after 3 months bone mineral density is normal

growth/size/body
increased body weight ( J:132629 )
• at 3 months

nervous system
nervous system phenotype ( J:132629 )
N
• mice exhibit normal brain and spinal cord morphology

hematopoietic system
decreased IgG level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
decreased IgM level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory