About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Leprtm2(cre)Rck
targeted mutation 2, Jeffrey M Friedman
MGI:3776158
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Tg(Tek-cre)12Flv/0 		involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL MGI:5306357
cn2
 		Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+ 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL MGI:5306356
cn3
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Leprtm2(cre)Rck/Lepr+ 		involves: C57BL/6 MGI:5488610


Genotype
MGI:5306357
cn1
Allelic
Composition		 Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (121 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system

growth/size/body
spleen hyperplasia ( J:180431 )




Genotype
MGI:5306356
cn2
Allelic
Composition		 Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematopoietic cell number ( J:180431 )
• in the bone marrow and the spleen
• depletion in the bone marrow increases over time

immune system

growth/size/body
enlarged spleen ( J:180431 )
spleen hyperplasia ( J:180431 )




Genotype
MGI:5488610
cn3
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Leprtm2(cre)Rck/Lepr+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (24 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:194748 )
• increased hematopoietic cells and colony forming cells in the blood and spleen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory