Phenotypes associated with this allele

• Allele Symbol: Tg(Vil1-CYP3A4)1Nki
• Allele Name: transgene insertion 1, The Netherlands Cancer Institute
• Allele ID: MGI:3775624
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cyp3a13^tm1Nki/Cyp3a13^tm1Nki Del(5Cyp3a57-Cyp3a59)2Nki/Del(5Cyp3a57-Cyp3a59)2Nki Tg(Vil1-CYP3A4)1Nki/0	involves: 129P2/OlaHsd * FVB/N	MGI:3775625
tg2	Tg(Vil1-CYP3A4)1Nki/0	involves: FVB/N	MGI:3775626

Genotype
MGI:3775625

cx1

• Allelic Composition: Cyp3a13^tm1Nki/Cyp3a13^tm1Nki; Del(5Cyp3a57-Cyp3a59)2Nki/Del(5Cyp3a57-Cyp3a59)2Nki; Tg(Vil1-CYP3A4)1Nki/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:127366 )

• docetaxel M-2 metabolites are not detected in hepatic microsomes unlike in wild-type microsomes treated with docetaxel

• however, M-2 metabolites are detected in intestinal microsomes

• docetaxel accumulation in the small intestines is decreased 4-fold compared to in Del(15Cyp3a57-Cyp3a59)1Ahs Cyp3a13^tm1Ahs homozygotes following intravenous injection of docetaxel

• however, upon oral administration of docetaxel plasma levels are reduced 16.6 fold compared to in Del(15Cyp3a57-Cyp3a59)1Ahs Cyp3a13^tm1Ahs homozygotes

• oral bioavailability is decreased to 1.8% compared to 8.1% in wild-type mice

• clearance of docetaxel is reduced compared to in wild-type mice

Genotype
MGI:3775626

tg2

• Allelic Composition: Tg(Vil1-CYP3A4)1Nki/0
• Genetic Background: involves: FVB/N

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:127366 )

• the mucosa of the small intestine exhibits increased cellularity at the villi and mild hypertrophic epithelium