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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxa2tm2.1(cre/Esr1*)Moon
targeted mutation 2.1, Anne M Moon
MGI:3774420
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Nkx2-5tm1Krc/Nkx2-5tm1Krc 		involves: 129 * C57BL/6 MGI:5643695
cn2
 		Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129S4/SvJaeSor MGI:3806653
cn3
 		Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+ 		involves: 129S6/SvEvTac * 129X1/SvJ MGI:3829047
cn4
 		Fgf8tm1Mrc/Fgf8tm2Moon
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+ 		Not Specified MGI:3829041


Genotype
MGI:5643695
cn1
Allelic
Composition		 Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2tm2.1(cre/Esr1*)Moon mutation (1 available); any Foxa2 mutation (26 available)
Nkx2-5tm1Krc mutation (0 available); any Nkx2-5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:214093 )
N
• pups from pregnant females treated with tamoxifen at E6.5-7 do not exhibit outflow tract septation or alignment defects




Genotype
MGI:3806653
cn2
Allelic
Composition		 Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2tm2.1(cre/Esr1*)Moon mutation (1 available); any Foxa2 mutation (26 available)
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:130990 )
• no developmental abnormalities are detected




Genotype
MGI:3829047
cn3
Allelic
Composition		 Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.2Cxd mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (88 available)
Foxa2tm2.1(cre/Esr1*)Moon mutation (1 available); any Foxa2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:143444 )
N
• despite disruption of vascular development mice survive to birth

cardiovascular system
cardiovascular system phenotype ( J:143444 )
N
• despite ubiquitous expression of these genes in the anterior of the embryo, no defects in outflow tract development are seen
abnormal vascular development ( J:143444 )
• disruption of vascular development




Genotype
MGI:3829041
cn4
Allelic
Composition		 Fgf8tm1Mrc/Fgf8tm2Moon
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1Mrc mutation (0 available); any Fgf8 mutation (18 available)
Fgf8tm2Moon mutation (0 available); any Fgf8 mutation (18 available)
Foxa2tm2.1(cre/Esr1*)Moon mutation (1 available); any Foxa2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:143444 )
N
• no defects in outflow tract development are seen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory