About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		n-TUtca2tm2.1Mym
targeted mutation 2.1, Masayuki Yamamoto
MGI:3772693
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3772771
cn2
 		Nfe2l2tm1Mym/Nfe2l2tm1Mym
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3772772
cn3
 		Nfe2l2tm1Mym/Nfe2l2tm1Mym
Tg(Alb1-cre)1Dlr/0
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:3772773


Genotype
MGI:3772771
cn1
Allelic
Composition		 n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:130723 )
• mice die between 1 and 3 months

cellular
increased cellular sensitivity to oxidative stress ( J:130723 )
• in culture, macrophages exhibit a 1.6-fold increase in intracellular reactive oxygen species levels at day 3 and a 2-fold increase at day 5 compared to in wild-type cells
increased apoptosis ( J:130723 )
• in culture, macrophage cell death increases from 6.2% in wild-type cells to 31%




Genotype
MGI:3772772
cn2
Allelic
Composition		 Nfe2l2tm1Mym/Nfe2l2tm1Mym
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Nfe2l2tm1Mym mutation (5 available); any Nfe2l2 mutation (88 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to oxidative stress ( J:130723 )
• production of oxygen reactive species is increased compared to when either gene product is absent
increased cellular sensitivity to hydrogen peroxide ( J:130723 )
• sensitivity to hydrogen peroxide treatment is increased compared to when either gene product is absent
increased apoptosis ( J:130723 )
• in culture, macrophage cell death increases from 6.2% in wild-type cells and in Trsp null cells 31% to 53%




Genotype
MGI:3772773
cn3
Allelic
Composition		 Nfe2l2tm1Mym/Nfe2l2tm1Mym
Tg(Alb1-cre)1Dlr/0
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2tm1Mym mutation (5 available); any Nfe2l2 mutation (88 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
Tg(Alb1-cre)1Dlr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, incomplete penetrance ( J:130723 )
• the highest mortality rates occur at 3 weeks of age
premature death ( J:130723 )
• all mice die by 7 weeks with the highest mortality rates at 3 weeks of age

liver/biliary system
increased hepatocyte apoptosis ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice
abnormal hepatocyte morphology ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte necrosis not observed in either single mutants or wild-type mice
liver degeneration ( J:130723 )
• at 3 weeks of age, mice exhibit liver degeneration not observed in either single mutants or wild-type mice

homeostasis/metabolism

cellular
increased hepatocyte apoptosis ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory