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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
n-TUtca2tm2.1Mym
targeted mutation 2.1, Masayuki Yamamoto
MGI:3772693
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3772771
cn2
Nfe2l2tm1Mym/Nfe2l2tm1Mym
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3772772
cn3
Nfe2l2tm1Mym/Nfe2l2tm1Mym
Tg(Alb1-cre)1Dlr/0
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:3772773


Genotype
MGI:3772771
cn1
Allelic
Composition
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (10 available); any Lyz2 mutation (15 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 1 and 3 months

cellular
• in culture, macrophage cell death increases from 6.2% in wild-type cells to 31%
• in culture, macrophages exhibit a 1.6-fold increase in intracellular reactive oxygen species levels at day 3 and a 2-fold increase at day 5 compared to in wild-type cells




Genotype
MGI:3772772
cn2
Allelic
Composition
Nfe2l2tm1Mym/Nfe2l2tm1Mym
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (10 available); any Lyz2 mutation (15 available)
Nfe2l2tm1Mym mutation (5 available); any Nfe2l2 mutation (64 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in culture, macrophage cell death increases from 6.2% in wild-type cells and in Trsp null cells 31% to 53%
• production of oxygen reactive species is increased compared to when either gene product is absent
• sensitivity to hydrogen peroxide treatment is increased compared to when either gene product is absent




Genotype
MGI:3772773
cn3
Allelic
Composition
Nfe2l2tm1Mym/Nfe2l2tm1Mym
Tg(Alb1-cre)1Dlr/0
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2tm1Mym mutation (5 available); any Nfe2l2 mutation (64 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
Tg(Alb1-cre)1Dlr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the highest mortality rates occur at 3 weeks of age
• all mice die by 7 weeks with the highest mortality rates at 3 weeks of age

liver/biliary system
• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice
• at 3 weeks of age, mice exhibit hepatocyte necrosis not observed in either single mutants or wild-type mice
• at 3 weeks of age, mice exhibit liver degeneration not observed in either single mutants or wild-type mice

homeostasis/metabolism

cellular
• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory