Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TNF*)K21Gkl mutation
(1 available)
Tnfrsf1atm1Blt mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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nervous system
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• neurological symptoms by the sixth month of age, delayed compared to Tg alone
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• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TNF*)K21Gkl mutation
(1 available)
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immune system
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• a progressive accumulation of inflammatory cells at one week of age
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nervous system
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• oligodendrocyte apoptosis starting at 2 weeks of age
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• a progressive accumulation of inflammatory cells at one week of age
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• at 4 weeks of age myelin loss is accompanied by astrocyte loss
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• widespread astrocytic gliosis starting at one week of age
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• blood-brain barrier damage at the meninges of the spinal cord starting at one week of age
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• at 4 weeks of age myelin loss is accompanied by axonal damage
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• by fourth week of age, demyelinating lesions cover 30% of the original myelin mass
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cellular
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• oligodendrocyte apoptosis starting at 2 weeks of age
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Analysis Tools