Mouse Genome Informatics
cx1
    Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+

involves: 129P2/OlaHsd * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• neurological symptoms by the sixth month of age, delayed compared to Tg alone
• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord

Mouse Models of Human Disease
OMIM IDRef(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:106592


Mouse Genome Informatics
tg2
    Tg(Gfap-TNF*)K21Gkl/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• a progressive accumulation of inflammatory cells at one week of age

nervous system
• oligodendrocyte apoptosis starting at 2 weeks of age
• a progressive accumulation of inflammatory cells at one week of age
• at 4 weeks of age myelin loss is accompanied by astrocyte loss
• widespread astrocytic gliosis starting at one week of age
• blood-brain barrier damage at the meninges of the spinal cord starting at one week of age
• by fourth week of age, demyelinating lesions cover 30% of the original myelin mass
• at 4 weeks of age myelin loss is accompanied by axonal damage

cellular
• oligodendrocyte apoptosis starting at 2 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:106592