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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Gfap-TNF*)K21Gkl
transgene insertion K21, George Kollias
MGI:3766134
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4461138
tg2
Tg(Gfap-TNF*)K21Gkl/0 involves: C57BL/6 * CBA MGI:4461137


Genotype
MGI:4461138
cx1
Allelic
Composition
Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TNF*)K21Gkl mutation (1 available)
Tnfrsf1atm1Blt mutation (5 available); any Tnfrsf1a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• neurological symptoms by the sixth month of age, delayed compared to Tg alone
• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:106592




Genotype
MGI:4461137
tg2
Allelic
Composition
Tg(Gfap-TNF*)K21Gkl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TNF*)K21Gkl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• a progressive accumulation of inflammatory cells at one week of age

nervous system
• oligodendrocyte apoptosis starting at 2 weeks of age
• a progressive accumulation of inflammatory cells at one week of age
• at 4 weeks of age myelin loss is accompanied by astrocyte loss
• widespread astrocytic gliosis starting at one week of age
• blood-brain barrier damage at the meninges of the spinal cord starting at one week of age
• at 4 weeks of age myelin loss is accompanied by axonal damage
• by fourth week of age, demyelinating lesions cover 30% of the original myelin mass

cellular
• oligodendrocyte apoptosis starting at 2 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:106592





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory