• neurological symptoms by the sixth month of age, delayed compared to Tg alone

• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord

• a progressive accumulation of inflammatory cells at one week of age

• oligodendrocyte apoptosis starting at 2 weeks of age

• a progressive accumulation of inflammatory cells at one week of age

• at 4 weeks of age myelin loss is accompanied by astrocyte loss

• widespread astrocytic gliosis starting at one week of age

• blood-brain barrier damage at the meninges of the spinal cord starting at one week of age

• by fourth week of age, demyelinating lesions cover 30% of the original myelin mass

• at 4 weeks of age myelin loss is accompanied by axonal damage

• oligodendrocyte apoptosis starting at 2 weeks of age