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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mnx1-cre)1Jrs
transgene insertion 1, Joshua R Sanes
MGI:3766074
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fgfr2tm1Dor/Fgfr2tm1Dor
Lamb2tm1Jrs/Lamb2tm1Jrs
Tg(Mnx1-cre)1Jrs/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3766403
cn2
 		Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Mnx1-cre)1Jrs/? 		involves: 129X1/SvJ * C57BL/6 MGI:3766402


Genotype
MGI:3766403
cn1
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Lamb2tm1Jrs/Lamb2tm1Jrs
Tg(Mnx1-cre)1Jrs/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (88 available)
Lamb2tm1Jrs mutation (1 available); any Lamb2 mutation (76 available)
Tg(Mnx1-cre)1Jrs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal synaptic vesicle clustering ( J:126496 )
• at P14, vesicles were highly clustered at synaptic site, but were abundant in preterminal portions




Genotype
MGI:3766402
cn2
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Mnx1-cre)1Jrs/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (88 available)
Tg(Mnx1-cre)1Jrs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:126496 )
• smaller than litter mate controls
• born in expected Mendelian numbers

behavior/neurological
tremors ( J:126496 )
• exhibited a mild tremor

nervous system
abnormal synaptic vesicle clustering ( J:126496 )
• at embryonic stages, vesicles were less concentrated at synaptic sites than in controls
• a similar defect was observed in neonates and during the first postnatal week
• the abnormality was transient and barely detectable by the third postnatal week
• neuromuscular junctions formed on schedule




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory