All Phenotypes Apc<tm1.1Tno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apc^tm1.1Tno
targeted mutation 1.1, Tetsuo Noda
MGI:3764940

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Apc^tm1.1Tno/Apc⁺	involves: 129S4/SvJae * C57BL/6	MGI:3764960
ht2	Apc^tm1.1Tno/Apc^tm1Tno	involves: 129 * 129S4/SvJae * BALB/cJ * C57BL/6	MGI:4429569
cx3	Apc^tm1.1Tno/Apc⁺ Ctnna1^del/Ctnna1⁺	involves: 129S4/SvJae * C57BL/6	MGI:3764961

Allelic Composition	Apc^tm1.1Tno/Apc⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1.1Tno mutation (0 available); any Apc mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:127452 )

• average lifespan is 22.5 weeks due to bowel obstructions and bleeding

neoplasm

increased intestinal adenoma incidence ( J:127452 )

• 7 to 50 fold more small intestine tumors as in wild-type controls, with the higher incidences occurring in the more distal portions of the small intestine

digestive/alimentary system

gastrointestinal hemorrhage ( J:127452 )

• severe bleeding often is cause of death

intestine polyps ( J:127452 )

• occurring frequently in the jejunum and ileum

increased intestinal adenoma incidence ( J:127452 )

• 7 to 50 fold more small intestine tumors as in wild-type controls, with the higher incidences occurring in the more distal portions of the small intestine

intestinal obstruction ( J:127452 )

• resulting from the numerous polyps in the small intestines

• major cause of death by 22.5 weeks of age

hematopoietic system

anemia ( J:127452 )

• resulting from intestinal bleeding

cardiovascular system

gastrointestinal hemorrhage ( J:127452 )

• severe bleeding often is cause of death

Allelic Composition	Apc^tm1.1Tno/Apc^tm1Tno
Genetic Background	involves: 129 * 129S4/SvJae * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1.1Tno mutation (0 available); any Apc mutation (154 available)
Apc^tm1Tno mutation (6 available); any Apc mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156864 )

• no mutant mice found at birth

nervous system

abnormal brain development ( J:156864 )

• embryos lack all structures anterior to the hindbrain at embryonic day 9.5 (E9.5), E12 and E16

absent midbrain ( J:156864 )

absent forebrain ( J:156864 )

craniofacial

absent mandible ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent mandible at E12

acrania ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent cranial structures at E12

skeleton

absent mandible ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent mandible at E12

acrania ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent cranial structures at E12

Allelic Composition	Apc^tm1.1Tno/Apc⁺ Ctnna1^del/Ctnna1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1.1Tno mutation (0 available); any Apc mutation (154 available)
Ctnna1^del mutation (0 available); any Ctnna1 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:127452 )

N	• the tumorigenic phenotype associated with the Apc^tm1.1Tno allele does not occur when both alleles are in a cis-configuration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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