Ctnna1^del
Spontaneous Allele Detail

Summary

• Symbol: Ctnna1^del
• Name: catenin alpha 1; deletion
• MGI ID: MGI:3764945
• Synonyms: Ctnna1^del
• Gene: Ctnna1 Location: Chr18:35251955-35387829 bp, + strand Genetic Position: Chr18, 18.89 cM
• Alliance: Ctnna1^del page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127452
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: A 4107 bp deletion encompassing exons 3 and 4 occurred in the locus, leading to a frameshift mutation at codon 101. Expression levels of the mutant allele are reduced by two-thirds as measured by RT-PCR analysis, and the protein generated is predicted to not be able to interact with its heterodimer partners. (J:127452)
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnna1 Mutation: 133 strains or lines available

Notes

This mutation arose on a APC^tm1.1Tno background and leads to a reversion of the tumorogenesis phenotype associated with the APC allele. This reversion only occurs when the two mutant alleles are in cis-configuration.

References

• Original: J:127452 Shibata H, et al., Alpha-catenin is essential in intestinal adenoma formation. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18199-204
• All: 1 reference(s)