Phenotypes associated with this allele

• Allele Symbol: Tert^tm1Sear
• Allele Name: targeted mutation 1, Steven E Artandi
• Allele ID: MGI:3764898
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tert^tm1Sear/Tert^tm1Sear	involves: 129S4/SvJae * C57BL/6	MGI:3764899
hm2	Tert^tm1Sear/Tert^tm1Sear	Not Specified	MGI:4352680

Genotype
MGI:3764899

hm1

• Allelic Composition: Tert^tm1Sear/Tert^tm1Sear
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal telomere length ( J:127153 )

• although telomere length in the first generation of mice are normal, by the fifth generation the number of chromosomes lacking telomeres is increased

increased apoptosis ( J:127153 )

• apoptosis in gastrointestinal crypts is increased by the fifth generation and cell half-life is decreased compared to in a wild-type mouse

• 86.2% of gastrointestinal crypt cells undergo S-phase prior to apoptosis

• apoptosis in gastrointestinal crypt cells does not require mitosis

Genotype
MGI:4352680

hm2

• Allelic Composition: Tert^tm1Sear/Tert^tm1Sear
• Genetic Background: Not Specified

skeleton

decreased rib number ( J:150343 )

• about half of the mice are missing the 13th rib on one or both sides due to vertebrae transformation

thoracic vertebral transformation ( J:150343 )

• about half of the first generational mice have transformation of the T13 vertebrae to L1

lumbar vertebral transformation ( J:150343 )

• some mice have transformation of the L6 to S1 vertebrae