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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trpc1tm1Lbi
targeted mutation 1, Lutz Birnbaumer
MGI:3764882
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trpc1tm1Lbi/Trpc1tm1Lbi involves: 129S/SvEv MGI:3764888
hm2
Trpc1tm1Lbi/Trpc1tm1Lbi involves: 129S/SvEv * C57BL/6 MGI:5474576
hm3
Trpc1tm1Lbi/Trpc1tm1Lbi involves: 129S/SvEv * C57BL/6J MGI:3765000
cx4
Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
involves: 129 * C57BL/6 MGI:5474577
cx5
Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:3810159
cx6
Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
Trpc6tm1Lbi/Trpc6tm1Lbi
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:3810160


Genotype
MGI:3764888
hm1
Allelic
Composition
Trpc1tm1Lbi/Trpc1tm1Lbi
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• carbachol or thapsigarin stimulated Ca2+ entry into submandibular gland acinar cells is reduced by over 60% compared to wild-type control cells
• both inward and outward store-operated cation currents are severely reduced in submandibular gland acinar cells
• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine
• however, submandibular gland morphology and size are similar to wild-type controls

endocrine/exocrine glands
• carbachol or thapsigarin stimulated Ca2+ entry into submandibular gland acinar cells is reduced by over 60% compared to wild-type control cells
• both inward and outward store-operated cation currents are severely reduced in submandibular gland acinar cells
• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine
• however, submandibular gland morphology and size are similar to wild-type controls

nervous system
N
• normal mGluR1 (Grm1) mediated synaptic transmission
• normal slow EPSC

homeostasis/metabolism
• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine
• however, submandibular gland morphology and size are similar to wild-type controls




Genotype
MGI:5474576
hm2
Allelic
Composition
Trpc1tm1Lbi/Trpc1tm1Lbi
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in pyramidal neurons from the CA1 region (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid induced bursts are retarded with reduced plateau amplitudes and spike numbers per burst

behavior/neurological
N
• severity of pilocarpine induced seizures is similar to controls




Genotype
MGI:3765000
hm3
Allelic
Composition
Trpc1tm1Lbi/Trpc1tm1Lbi
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• despite expression and activity results from previous studies and in other species no abnormalities are seen in store-operated or mechanosensitive cation channels in vascular smooth muscle cells

growth/size/body




Genotype
MGI:5474577
cx4
Allelic
Composition
Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (26 available)
Trpc4tm1Bni mutation (0 available); any Trpc4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in pyramidal neurons from the CA1 region (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid induced bursts are retarded with reduced plateau amplitudes and spike numbers per burst




Genotype
MGI:3810159
cx5
Allelic
Composition
Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (26 available)
Trpc4tm1Bni mutation (0 available); any Trpc4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• normal mGluR1 (Grm1) mediated synaptic transmission
• normal slow EPSC




Genotype
MGI:3810160
cx6
Allelic
Composition
Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
Trpc6tm1Lbi/Trpc6tm1Lbi
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (26 available)
Trpc4tm1Bni mutation (0 available); any Trpc4 mutation (33 available)
Trpc6tm1Lbi mutation (1 available); any Trpc6 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• normal mGluR1 (Grm1) mediated synaptic transmission
• normal slow EPSC





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory