Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation
(3 available);
any
Git2 mutation
(78 available)
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hematopoietic system
immune system
behavior/neurological
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• delayed response in the hot plate test in female mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation
(3 available);
any
Git2 mutation
(78 available)
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hematopoietic system
immune system
Allelic
Composition |
Git2Gt(XG510)Byg/Git2+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation
(3 available);
any
Git2 mutation
(78 available)
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normal phenotype
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• mice are normal with no differences in body size, organ size, overt behavior, or fertility when compared to wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation
(3 available);
any
Git2 mutation
(78 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation
(3 available)
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hematopoietic system
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• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired
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• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired
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immune system
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• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired
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• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired
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cellular
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• in the absence of any stimulus basal migration is modestly but consistently greater for the CD4SP and CD8SP subsets of thymocytes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation
(3 available);
any
Git2 mutation
(78 available)
Tg(DO11.10)10Dlo mutation
(7 available)
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hematopoietic system
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• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood
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immune system
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• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation
(3 available);
any
Git2 mutation
(78 available)
Tg(TcraTcrb)425Cbn mutation
(3 available)
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hematopoietic system
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• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood
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immune system
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• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood
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Analysis Tools
