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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il1rl2tm1Hblu
targeted mutation 1, Hal Blumberg
MGI:3762029
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il1rl2tm1Hblu/Il1rl2tm1Hblu involves: 129 MGI:5476732
hm2
 		Il1rl2tm1Hblu/Il1rl2tm1Hblu involves: 129 * C57BL/6 MGI:3762040
cx3
 		Il1rl2tm1Hblu/Il1rl2+
Tg(KRT14-Il1f6)1Hblu/? 		involves: 129 * C57BL/6 * DBA/2 MGI:3762041
cx4
 		Il1rl2tm1Hblu/Il1rl2tm1Hblu
Tg(KRT14-Il1f6)1Hblu/? 		involves: 129 * C57BL/6 * DBA/2 MGI:3762042


Genotype
MGI:5476732
hm1
Allelic
Composition		 Il1rl2tm1Hblu/Il1rl2tm1Hblu
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rl2tm1Hblu mutation (0 available); any Il1rl2 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Il1rl2tm1Hblu/Il1rl2tm1Hblu and Il36rntm1Kopf/Il36rntm1Kopf mice show different susceptibilities to IMQ-induced psoriasiform dermatitis

digestive/alimentary system
decreased susceptibility to induced colitis ( J:256437 )
• mice treated with the hapten oxazolone to induce colitis (a TH2/9 model of colitis) show reduced weight loss and colonic inflammation compared to wild-type mice

immune system
decreased susceptibility to induced colitis ( J:256437 )
• mice treated with the hapten oxazolone to induce colitis (a TH2/9 model of colitis) show reduced weight loss and colonic inflammation compared to wild-type mice
increased regulatory T cell number ( J:256437 )
• following oxazolone-induced colitis, mice show increased frequency and absolute number of Helios-Foxp3+CD4+ T cells in colonic tissue indicating increased colonic T-reg cells
decreased leukocyte cell number ( J:193548 )
• in the skin of IMQ-treated mice
decreased neutrophil cell number ( J:193548 )
• in the skin of IMQ-treated mice
• in skin-draining lymph nodes of IMQ-treated mice
decreased gamma-delta T cell number ( J:193548 )
• decreased IL17A-producing gamma-delta T cells in IMQ-treated mice
decreased macrophage cell number ( J:193548 )
• in skin-draining lymph nodes of IMQ-treated mice
abnormal lymph node morphology ( J:193548 )
• reduced cellularity of skin-draining lymph nodes of IMQ-treated mice
decreased interleukin-17 secretion ( J:193548 )
• decreased IL17A-producing gamma-delta T cells in IMQ-treated mice
decreased interleukin-9 secretion ( J:256437 )
• following oxazolone-induced colitis, mice show reduced IL-9 production by colonic lamina propria lymphocytes

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:193548 )
• mice are protected from IMQ (Aldara)-induced psoriasis with decreased ear swelling, acanthosis, erythema, skin flaking and hyperkeratosis compared with wild-type mice

hematopoietic system
increased regulatory T cell number ( J:256437 )
• following oxazolone-induced colitis, mice show increased frequency and absolute number of Helios-Foxp3+CD4+ T cells in colonic tissue indicating increased colonic T-reg cells
decreased leukocyte cell number ( J:193548 )
• in the skin of IMQ-treated mice
decreased neutrophil cell number ( J:193548 )
• in the skin of IMQ-treated mice
• in skin-draining lymph nodes of IMQ-treated mice
decreased gamma-delta T cell number ( J:193548 )
• decreased IL17A-producing gamma-delta T cells in IMQ-treated mice
decreased macrophage cell number ( J:193548 )
• in skin-draining lymph nodes of IMQ-treated mice




Genotype
MGI:3762040
hm2
Allelic
Composition		 Il1rl2tm1Hblu/Il1rl2tm1Hblu
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rl2tm1Hblu mutation (0 available); any Il1rl2 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal macrophage activation involved in immune response ( J:296074 )
• bone marrow derived macrophages exhibit reduced phagocytosis when incubated with labeled Streptococcus pneumoniae

immune system
abnormal macrophage activation involved in immune response ( J:296074 )
• bone marrow derived macrophages exhibit reduced phagocytosis when incubated with labeled Streptococcus pneumoniae
abnormal dendritic cell physiology ( J:296074 )
• cytokine induction in response to Il1f9 (IL-36gamma) is impaired in bone marrow-derived dendritic cells

normal phenotype
no abnormal phenotype detected ( J:126327 )
• mice display no overt phenotype including normal skin




Genotype
MGI:3762041
cx3
Allelic
Composition		 Il1rl2tm1Hblu/Il1rl2+
Tg(KRT14-Il1f6)1Hblu/?
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rl2tm1Hblu mutation (0 available); any Il1rl2 mutation (45 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal skin morphology ( J:126327 )
• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice




Genotype
MGI:3762042
cx4
Allelic
Composition		 Il1rl2tm1Hblu/Il1rl2tm1Hblu
Tg(KRT14-Il1f6)1Hblu/?
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rl2tm1Hblu mutation (0 available); any Il1rl2 mutation (45 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:126327 )
N
• mice have normal skin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory