Analysis Tools
mortality/aging
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• mice are observed at Mendelian ratios at E8.5 but deteriorate at E10.5 to E12.5 and by E13.5 are completely absorbed
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embryo
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• at E9.5, no obvious blood vessels are present in the yolk sacs
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• at E8.5, some mice exhibit no turning
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• at E9.5, mice have not completed turning
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• at E9.5, embryonic development arrests after forming 15 somites
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• at E8.5, some mice are smaller than normal
• at E9.5, mice are grossly smaller than normal
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spina bifida
(
J:125199
)
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• at E9.5, mice exhibit open anterior and posterior neural tube pores
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• at E9.5, mice exhibit undulating neural tubes
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• 3 of 12 mice have balloon-shaped allantois that is associated with less severe vasculature abnormalities
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• placenta are thinner and contain fewer erythrocytes than in wild-type mice
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• blood islands are occasionally dilated and fail to coalesce to form the primitive vascular plexus
• however, blood islands form normally
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• at E9.5, mice exhibit pale yolk sacs with no obvious blood vessels
• few erythrocytes are found in the blood islands
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cardiovascular system
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• at E9.5, most mice lack major blood vessels
• however, delicate plexus-like structures at the site of the dorsal aorta are present
• 3 of 12 mice have balloon-shaped allantois that is associated with less severe vasculature abnormalities
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• embryonic and extra-embryonic vasulogenesis is defective
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• at E9.5, no obvious blood vessels are present in the yolk sacs
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nervous system
spina bifida
(
J:125199
)
|
• at E9.5, mice exhibit open anterior and posterior neural tube pores
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• at E9.5, mice exhibit undulating neural tubes
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anencephaly
(
J:125199
)
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• at E9.5, mice exhibit open anterior and posterior neural tube pores
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growth/size/body
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• at E8.5, some mice are smaller than normal
• at E9.5, mice are grossly smaller than normal
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hematopoietic system
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• few erythrocytes are found in the blood islands and placenta
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