Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-tetX,lacZ)1Gogo mutation
(1 available)
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nervous system
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• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited
(J:124050)
• following doxycycline treatment, the number of terminal branches of olfactory nerves is modestly increased relative to in wild-type mice
(J:124050)
• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited
(J:124299)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Or10a4tm1Mom mutation
(7 available);
any
Or10a4 mutation
(22 available)
Tg(tetO-APPSwInd)Dbo mutation
(0 available)
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craniofacial
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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growth/size/body
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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nervous system
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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• no obvious Olfr17+ axonal convergence is seen in the olfactory bulb
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respiratory system
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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taste/olfaction
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Omptm2(spH)Mom mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-APPSwInd)Dbo mutation
(0 available)
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taste/olfaction
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• mice show virtually no detectable focal signals when presented with the an array of odors, suggesting loss of olfactory function
• administration of doxycycline from 3 to 4 weeks of age, results in modest odor-induced SpH-signals, while administration for 3 weeks, further restores odor-induced signals, with more glomeruli activated by odors
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Or8a1tm25Mom mutation
(6 available);
any
Or8a1 mutation
(69 available)
Tg(tetO-APPSwInd)Dbo mutation
(0 available)
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craniofacial
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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growth/size/body
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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nervous system
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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respiratory system
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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taste/olfaction
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-APPSwInd)Dbo mutation
(0 available)
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craniofacial
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• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
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• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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growth/size/body
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• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
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• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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nervous system
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
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• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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• structure of the olfactory bulb is altered
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• the glomerular layer is thinner, with a massive loss of glomeruli
• treatment with doxycycline restores the glomerular layer, although the glomerular layer appears disorganized
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• outer nerve layer is thinner
• increase in apoptosis in the outer nerve layer
• treatment with doxycycline restores the outer nerve layer
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• reduction in size of the olfactory bulb
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• mice show a reduction in VGlu2 staining, indicating loss of olfactory sensory neuron axon terminals in the olfactory bulb
• treatment with doxycycline restores these axon terminals in the olfactory bulb
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• neurodegeneration of olfactory sensory neurons, with most lost between 7 and 14 days of age
• treatment with doxycycline reverses neurodegeneration
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• rapid and widespread apoptosis in mature olfactory sensory neurons
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respiratory system
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• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
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• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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• rapid and widespread apoptosis in mature olfactory sensory neurons
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taste/olfaction
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• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
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• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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• rapid and widespread apoptosis in mature olfactory sensory neurons
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• in a buried food assay, mice take a longer time to find the cookie
• in an avoidance assay in which the simple odorant isovaleric acid is added to drinking water and becomes an aversive stimulus associated with an LiCl injection, the conditioned mutants show a higher preference for the odor-water than controls, indicating decreased ability to detect the odor
• administration of doxycycline restores odor detection in both the buried food assay and at high concentration of isovaleric acid in the avoidance assay
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation
(1 available)
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nervous system
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• following doxycycline treatment, organization of the glomeruli in the dorsal part of the bulb remains disorganized, thinly innervated, necklace glomeruli are absent, and nerves that enter the bulb coalesce into a giant glomerulus-like structure
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• following doxycycline treatment, the spiking activity of olfactory nerves is inhibited
• following doxycycline treatment, the entry of the sensory neuron into the olfactory bulb is delayed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Or4e5tm2Rax mutation
(0 available);
any
Or4e5 mutation
(20 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation
(1 available)
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nervous system
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• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and 75% of those that enter the olfactory bulb innervate two to three glomeruli in the ventral portion of the bulb
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Or10a4tm6Rax mutation
(0 available);
any
Or10a4 mutation
(22 available)
Tg(tetO-Kcnj2,lacZ)1Gogo mutation
(1 available)
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nervous system
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• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and those that enter the olfactory bulb sparsely innervate an average of 16 glomeruli in the ventral portion of the bulb
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation
(2 available);
any
Ngfr mutation
(30 available)
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation
(0 available)
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nervous system
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• following doxycycline treatment, terminal-arbor complexity is partially rescued (4 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omptm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation
(2 available);
any
Ngfr mutation
(30 available)
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation
(0 available)
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nervous system
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• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is rescued with 7 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omptm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice but branching length is not restored
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Jae mutation
(2 available);
any
Bdnf mutation
(39 available)
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation
(0 available)
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nervous system
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N |
• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is normal
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nervous system
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• the positive effect of global presynaptic inactinity on the total branch length is somewhat attenuated
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm2(BDNF)Gogo mutation
(0 available);
any
Bdnf mutation
(39 available)
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation
(0 available)
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nervous system
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• following doxycycline treatment, terminal-arbor complexity at P6 is reduced similar to in Tg(tetO-tetX,lacZ)2Gogo Omptm1(tTA)Gogo mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1(BDNF)Gogo mutation
(0 available);
any
Bdnf mutation
(39 available)
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation
(0 available)
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nervous system
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N |
• following doxycycline treatment, terminal-arbor complexity and total length of olfactory nerve axons is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation
(1 available);
any
Omp mutation
(27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation
(0 available)
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nervous system
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• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited
• following doxycycline treatment, P6 mice exhibit a reduction in terminal-arbor complexity (1.96+/-0.17 branches per axon arbor compared to 6.6+/-0.19 in wild-type mice) and total length (153.29+/-13.16 um compared to 231.6+/-0.19 um in wild-type mice)
• following doxycycline treatment, large axonal varicosities are increased as are signs of degeneration
• however, normal branching can be reconstituted with the application of an NMDR inhibitor (MK-801)
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Analysis Tools