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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atf7tm1Nicj
targeted mutation 1, Nic Jones
MGI:3720869
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atf7tm1Nicj/Atf7tm1Nicj B6.129P2-Atf7tm1Nicj MGI:3721131
cx2
Atf2tm1Nicj/Atf2tm1Nicj
Atf7tm1Nicj/Atf7tm1Nicj
involves: 129P2/OlaHsd * C57BL/6 MGI:3721133
cx3
Atf2tm2Nicj/Atf2tm2Nicj
Atf7tm1Nicj/Atf7tm1Nicj
involves: 129P2/OlaHsd * C57BL/6 MGI:3721134


Genotype
MGI:3721131
hm1
Allelic
Composition
Atf7tm1Nicj/Atf7tm1Nicj
Genetic
Background
B6.129P2-Atf7tm1Nicj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf7tm1Nicj mutation (0 available); any Atf7 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and have no gross abnormalities




Genotype
MGI:3721133
cx2
Allelic
Composition
Atf2tm1Nicj/Atf2tm1Nicj
Atf7tm1Nicj/Atf7tm1Nicj
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Nicj mutation (0 available); any Atf2 mutation (46 available)
Atf7tm1Nicj mutation (0 available); any Atf7 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
• E12.5 myeloid and erythroid precursors from the liver form fewer hematopoeitic colonies compared to wild-type cells
• some pups recovered between E11.5 and E12.5 are anemic

embryo
• some pups recovered between E11.5 and E12.5 exhibit developmental arrest and death
• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

growth/size/body
• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation




Genotype
MGI:3721134
cx3
Allelic
Composition
Atf2tm2Nicj/Atf2tm2Nicj
Atf7tm1Nicj/Atf7tm1Nicj
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm2Nicj mutation (0 available); any Atf2 mutation (46 available)
Atf7tm1Nicj mutation (0 available); any Atf7 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

liver/biliary system
• at E11.5, a large increase in apoptotic liver cells is observed
• some pups recovered between E11.5 and E12.5 exhibit defects in liver architecture
• normal sized livers have severe tissue loss accompanied by expansion of sinuses
• a moderate decrease in proliferating liver cells and a large increase in apoptotic liver cells are observed even prior to reduction in liver size
• fewer erythropoeitic (Ter119+) cells are found due to increased apoptosis
• some pups recovered between E11.5 and E12.5 exhibit liver hypoplasia

hematopoietic system
• E12.5 myeloid and erythroid precursors from the liver form fewer hematopoeitic colonies compared to wild-type cells
• some pups recovered between E11.5 and E12.5 are anemic

cardiovascular system
• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages
• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages

embryo
• some pups recovered between E11.5 and E12.5 exhibit developmental arrest and death
• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

cellular
• hepatocytes and hematopoeitic cells of the liver undergo increased amounts of apoptosis
• explanted fetal liver cells grown in culture barely increase in cell number whereas wild-type cells double every 24 hours due to an increase in apoptosis
• at E11.5, a large increase in apoptotic liver cells is observed
• explanted fetal liver cells grown in culture barely increase in cell number whereas wild-type cells double every 24 hours due to an increase in apoptosis

growth/size/body
• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

homeostasis/metabolism
• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages





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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory