Analysis Tools
normal phenotype
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• mice are viable and have no gross abnormalities
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Allele Symbol Allele Name Allele ID |
Atf7tm1Nicj targeted mutation 1, Nic Jones MGI:3720869 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and have no gross abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pups die between E11.5 and E12.5
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• E12.5 myeloid and erythroid precursors from the liver form fewer hematopoeitic colonies compared to wild-type cells
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• some pups recovered between E11.5 and E12.5 exhibit developmental arrest and death
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• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation
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• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pups die between E11.5 and E12.5
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• at E11.5, a large increase in apoptotic liver cells is observed
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• some pups recovered between E11.5 and E12.5 exhibit defects in liver architecture
• normal sized livers have severe tissue loss accompanied by expansion of sinuses
• a moderate decrease in proliferating liver cells and a large increase in apoptotic liver cells are observed even prior to reduction in liver size
• fewer erythropoeitic (Ter119+) cells are found due to increased apoptosis
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• some pups recovered between E11.5 and E12.5 exhibit liver hypoplasia
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• E12.5 myeloid and erythroid precursors from the liver form fewer hematopoeitic colonies compared to wild-type cells
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• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages
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• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages
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• some pups recovered between E11.5 and E12.5 exhibit developmental arrest and death
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• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation
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• hepatocytes and hematopoeitic cells of the liver undergo increased amounts of apoptosis
• explanted fetal liver cells grown in culture barely increase in cell number whereas wild-type cells double every 24 hours due to an increase in apoptosis
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• at E11.5, a large increase in apoptotic liver cells is observed
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• explanted fetal liver cells grown in culture barely increase in cell number whereas wild-type cells double every 24 hours due to an increase in apoptosis
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• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation
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• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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