Phenotypes associated with this allele
behavior/neurological
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• almost all animals display essentially no circadian rhythmicity (no clear circadian peak)
• under light-dark conditions (LD; 12:12 light/dark cycle), mutants are more active than wild-type in the light phase
• in animals, decreasing circadian amplitudes correlate with increasing ultradian amplitudes
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behavior/neurological
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• animals display impaired activity rhythms but are not totally arrhythmic
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• animals have a shorter period in constant light conditions (DD); mutants have higher onset errors than wild-type controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmal1tm1Weit mutation
(1 available);
any
Bmal1 mutation
(137 available)
Syt10tm1.1(icre)Geno mutation
(0 available);
any
Syt10 mutation
(35 available)
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behavior/neurological
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• mice show a shortened period under constant dark conditions (DD) compared to controls; animals are still rhythmic under constant light and dark conditions, but rhythmicity under DD is less stable compared to controls (mutants show increased onset variability relative to controls)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmal1tm1Weit mutation
(1 available);
any
Bmal1 mutation
(137 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation
(1 available)
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vision/eye
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• under dark-adapted conditions, amplitude of b-wave is reduced by 27%, causing significant reduction in b-wave to a-wave amplitude ratio
• under light-adapted conditions, b-wave amplitude is reduced by 44%
• no detectable circadian rhythm of b-wave amplitude is observed, with b-wave responses apparently fixed at low amplitude at times of both high and low b-wave amplitude (circadian times CT 6 and CT 18)
• no circadian rhythm of b-wave implicit time (time between light stimulus and peak of b-wave) is detectable, whereas this is robust in controls
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Analysis Tools