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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shc1tm9.1Paw
targeted mutation 9.1, Tony Pawson
MGI:3717010
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Shc1tm8Paw/Shc1tm9.1Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717095
cn2
 		Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw 		involves: 129S1/Sv * 129X1/SvJ MGI:3717101
cn3
 		Shc1tm8Paw/Shc1tm9.1Paw
Tg(Myh6-cre)2182Mds/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3717096


Genotype
MGI:3717095
ht1
Allelic
Composition		 Shc1tm8Paw/Shc1tm9.1Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm8Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:122927 )
• between E12.5 and 13.5, all mutant embryos are dead




Genotype
MGI:3717101
cn2
Allelic
Composition		 Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (0 available); any Isl1 mutation (33 available)
Shc1tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:122927 )
• mutants appear normal




Genotype
MGI:3717096
cn3
Allelic
Composition		 Shc1tm8Paw/Shc1tm9.1Paw
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm8Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:122927 )
• between E12.5 and 13.5, 8/19 mutant embryos are dead, compared to all mutant embryos not expressing the cre-recombined allele; remaining embryos have regularly beating hearts and normal-appearing trabeculae




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory