All Phenotypes Tctn1<Gt(KST296)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tctn1^{Gt(KST296)Byg}
gene trap KST296, BayGenomics
MGI:3716885

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg}	B6.129P2-Tctn1^{Gt(KST296)Byg}	MGI:3717154
hm2	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg}	involves: 129P2/OlaHsd	MGI:5292229
cx3	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Tmem67^tm1Dgen/Tmem67^tm1Dgen	B6.129P2-Tmem67^tm1Dgen Tctn1^{Gt(KST296)Byg}	MGI:5292227
cx4	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Shh^tm1Chg/Shh^tm1Chg	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3717155
cx5	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Smo^tm1Amc/Smo^tm1Amc	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3717156

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg}
Genetic Background	B6.129P2-Tctn1^{Gt(KST296)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:103820 )

• mice die between E13.4 and E16.5

nervous system

absent floor plate ( J:103820 )

small embryonic telencephalon ( J:103820 )

• telencephalon is smaller than in wild-type mice

holoprosencephaly ( J:103820 )

embryo

absent floor plate ( J:103820 )

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:176174 )

N	• cilia forms in the notochord and limb bud mesenchymal

absent embryonic cilia ( J:176174 )

• at E8.5

abnormal left-right axis patterning ( J:176174 )

• mice exhibit disrupted nodal flow and left lateral plate induction of Nodal gene expression compared with wild-type mice

abnormal rostral-caudal axis patterning ( J:176174 )

• variable curvature

abnormal embryonic neuroepithelium morphology ( J:176174 )

• at E10.5, cilia are scarse in the neural tube compared to in control mice

• neural tube cilia are short and bulbous unlike in control mice

nervous system

abnormal embryonic neuroepithelium morphology ( J:176174 )

• at E10.5, cilia are scarse in the neural tube compared to in control mice

• neural tube cilia are short and bulbous unlike in control mice

limbs/digits/tail

preaxial polydactyly ( J:176174 )

• in the hindlimb

cellular

cellular phenotype ( J:176174 )

N	• mouse embryonic fibroblasts develop cilia

absent embryonic cilia ( J:176174 )

• at E8.5

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Tmem67^tm1Dgen/Tmem67^tm1Dgen
Genetic Background	B6.129P2-Tmem67^tm1Dgen Tctn1^{Gt(KST296)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (33 available)
Tmem67^tm1Dgen mutation (2 available); any Tmem67 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic tissue morphology ( J:176174 )

• mice exhibit the same defects as in Tctn1^{Gt(KST296)Byg} homozygotes

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Shh^tm1Chg/Shh^tm1Chg
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (1 available); any Shh mutation (45 available)
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased forebrain size ( J:103820 )

• forebrains are larger than in Shh^tm1Chg

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Smo^tm1Amc/Smo^tm1Amc
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smo^tm1Amc mutation (1 available); any Smo mutation (39 available)
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased forebrain size ( J:103820 )

• forebrains are larger than in Smo^tm1Amc

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