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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcg1tm1Asch
targeted mutation 1, A Schurmann
MGI:3715323
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abcg1tm1Asch/Abcg1tm1Asch involves: 129X1/SvJ * C57BL/6 MGI:3715326


Genotype
MGI:3715326
hm1
Allelic
Composition
Abcg1tm1Asch/Abcg1tm1Asch
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg1tm1Asch mutation (1 available); any Abcg1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• when fed a high fat diet, adipocytes are lower in size compared to in wild-type mice

homeostasis/metabolism
• when fed a high fat diet, fasting blood glucose levels are significantly lower than in wild-type mice
• when fed a high fat diet
• 748.1+/-5.4 kJ/d.kgMBM compared to 684.3+/-5.0 kJ/d.kgMBM in wild-type when fed a high fat diet
• when fed a high fat diet (containing 35% of total calories from fat), mice have significantly lower body weight gain compared to wild-type mice
• fat accumulation is reduced when fed a high fat diet (3.8+/-1.3 g of body fat gain compared to 9.4+/-1.59 g body fat gain in wild-type mice)
• 34.163+/-0.190 L/d>kg compared to 31.289+/-0.24 L/d.kg in wild-type mice when fed a high fat diet

adipose tissue
• when fed a high fat diet, brown adipose tissue cells are smaller than in wild-type mice
• when fed a high fat diet, adipocytes are lower in size compared to in wild-type mice

liver/biliary system

growth/size/body
• when fed a high fat diet (containing 35% of total calories from fat), mice have significantly lower body weight gain compared to wild-type mice
• fat accumulation is reduced when fed a high fat diet (3.8+/-1.3 g of body fat gain compared to 9.4+/-1.59 g body fat gain in wild-type mice)





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory