Abcg1^tm1Asch
Targeted Allele Detail

Summary

• Symbol: Abcg1^tm1Asch
• Name: ATP binding cassette subfamily G member 1; targeted mutation 1, A Schurmann
• MGI ID: MGI:3715323
• Synonyms: Abcg1^-
• Gene: Abcg1 Location: Chr17:31276668-31336958 bp, + strand Genetic Position: Chr17, 15.8 cM, cytoband A2-B
• Alliance: Abcg1^tm1Asch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122438
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette was inserted into exons 3 and 5 replacing the intervening sequence. The absence of protein expression was confirmed by western blot analysis. (J:122438)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcg1 Mutation: 45 strains or lines available

References

• Original: J:122438 Buchmann J, et al., Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity. Endocrinology. 2007 Apr;148(4):1561-73
• All: 1 reference(s)