All Phenotypes Sun1<tm1Mhan> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sun1^tm1Mhan/Sun1^tm1Mhan	B6.129S6-Sun1^tm1Mhan	MGI:5566679
hm2	Sun1^tm1Mhan/Sun1^tm1Mhan	involves: 129S6/SvEvTac	MGI:3715729
hm3	Sun1^tm1Mhan/Sun1^tm1Mhan	involves: 129S6/SvEvTac * C57BL/6J	MGI:5615704
cx4	Sun1^tm1Mhan/Sun1⁺ Sun2^tm1Mhan/Sun2^tm1Mhan	involves: 129S6/SvEvTac	MGI:3850094
cx5	Sun1^tm1Mhan/Sun1^tm1Mhan Sun2^tm1Mhan/Sun2^tm1Mhan	involves: 129S6/SvEvTac	MGI:3850092
cx6	Sun1^tm1Mhan/Sun1^tm1Mhan Sun2^tm1Mhan/Sun2⁺	involves: 129S6/SvEvTac	MGI:3850093
cx7	Rad21l^tm1Yow/Rad21l^tm1Yow Sun1^tm1Mhan/Sun1^tm1Mhan	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5615731

Allelic Composition	Sun1^tm1Mhan/Sun1^tm1Mhan
Genetic Background	B6.129S6-Sun1^tm1Mhan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1^tm1Mhan mutation (1 available); any Sun1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:205574 )

• chromosome movement is impaired

• defect in telomere-nuclear envelope attachment

abnormal meiotic attachment of telomere to nuclear envelope ( J:205574 )

• defect in telomere-nuclear envelope attachment

cellular

abnormal male meiosis ( J:205574 )

• chromosome movement is impaired

• defect in telomere-nuclear envelope attachment

abnormal meiotic attachment of telomere to nuclear envelope ( J:205574 )

• defect in telomere-nuclear envelope attachment

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent oocytes ( J:122602 )

• no oocytes are detected at day 5

abnormal spermatocyte morphology ( J:122602 )

• only abnormal spermatocyte-like cells are present

decreased male germ cell number ( J:122602 )

• germ cells are largely depleted in seminiferous tubules

• spermatids and spermatozoa are completely absent

abnormal chromosomal synapsis ( J:122602 )

• no spermatocytes show normal homologous pairing and synapsis

abnormal female meiosis ( J:122602 )

• oocytes fail to form normal nuclear attachment and clustering of telomeres

• very rarely are pachytene-like structures observed

arrest of male meiosis ( J:122602 )

• spermatogenesis is arrested in meiotic prophase

• spermatocytes fail to form normal nuclear attachment and clustering of telomeres

• no spermatocytes show normal homologous pairing and synapsis

increased ovary apoptosis ( J:122602 )

• at E17.5, ovaries have increased apoptotic signal

increased testis apoptosis ( J:122602 )

• apoptotic signal in the seminiferous tubules is increased

absent ovarian follicles ( J:122602 )

small ovary ( J:122602 )

small testis ( J:122602 )

female infertility ( J:122602 )

male infertility ( J:122602 )

cellular

absent oocytes ( J:122602 )

• no oocytes are detected at day 5

abnormal spermatocyte morphology ( J:122602 )

• only abnormal spermatocyte-like cells are present

decreased male germ cell number ( J:122602 )

• germ cells are largely depleted in seminiferous tubules

• spermatids and spermatozoa are completely absent

abnormal chromosomal synapsis ( J:122602 )

• no spermatocytes show normal homologous pairing and synapsis

abnormal female meiosis ( J:122602 )

• oocytes fail to form normal nuclear attachment and clustering of telomeres

• very rarely are pachytene-like structures observed

arrest of male meiosis ( J:122602 )

• spermatogenesis is arrested in meiotic prophase

• spermatocytes fail to form normal nuclear attachment and clustering of telomeres

• no spermatocytes show normal homologous pairing and synapsis

increased ovary apoptosis ( J:122602 )

• at E17.5, ovaries have increased apoptotic signal

increased testis apoptosis ( J:122602 )

• apoptotic signal in the seminiferous tubules is increased

hearing/vestibular/ear

abnormal cochlear outer hair cell morphology ( J:194486 )

• outer hair cells exhibit abnormal positioning of the nucleus compared with wild-type mice

cochlear outer hair cell degeneration ( J:194486 )

increased or absent threshold for auditory brainstem response ( J:194486 )

• at P30

behavior/neurological

absent pinna reflex ( J:194486 )

muscle

abnormal muscle morphology ( J:150047 )

• mice exhibit a modest decrease in the average number of synaptic nuclei beneath the neuromuscular junctions compared with wild-type mice

nervous system

abnormal cochlear outer hair cell morphology ( J:194486 )

• outer hair cells exhibit abnormal positioning of the nucleus compared with wild-type mice

cochlear outer hair cell degeneration ( J:194486 )

endocrine/exocrine glands

increased ovary apoptosis ( J:122602 )

• at E17.5, ovaries have increased apoptotic signal

increased testis apoptosis ( J:122602 )

• apoptotic signal in the seminiferous tubules is increased

absent ovarian follicles ( J:122602 )

small ovary ( J:122602 )

small testis ( J:122602 )

Allelic Composition	Sun1^tm1Mhan/Sun1^tm1Mhan
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1^tm1Mhan mutation (1 available); any Sun1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:209347 )

• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes

• homolog association and pairing progress slowly in spermatocytes

abnormal male meiosis ( J:209347 )

• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes

• the initial chromosome association at the early leptotene stage is delayed in spermatocytes, indicating that homolog association and pairing progress slowly in spermatocytes

cellular

abnormal chromosomal synapsis ( J:209347 )

• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes

• homolog association and pairing progress slowly in spermatocytes

abnormal male meiosis ( J:209347 )

• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes

• the initial chromosome association at the early leptotene stage is delayed in spermatocytes, indicating that homolog association and pairing progress slowly in spermatocytes

Allelic Composition	Sun1^tm1Mhan/Sun1⁺ Sun2^tm1Mhan/Sun2^tm1Mhan
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1^tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
Sun2^tm1Mhan mutation (1 available); any Sun2 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle morphology ( J:150047 )

• 49% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice

Allelic Composition	Sun1^tm1Mhan/Sun1^tm1Mhan Sun2^tm1Mhan/Sun2^tm1Mhan
Genetic Background	involves: 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:150047 )

• mice die soon after birth

• however, neural expression of Unc84b rescues neonatal lethality

muscle

abnormal muscle morphology ( J:150047 )

• 81% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice

growth/size/body

decreased birth body size ( J:150047 )

• reduced body size at birth

homeostasis/metabolism

cyanosis ( J:150047 )

• at birth

Allelic Composition	Sun1^tm1Mhan/Sun1^tm1Mhan Sun2^tm1Mhan/Sun2⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle morphology ( J:150047 )

• 63% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice

Allelic Composition	Rad21l^tm1Yow/Rad21l^tm1Yow Sun1^tm1Mhan/Sun1^tm1Mhan
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^tm1Yow mutation (1 available); any Rad21l mutation (34 available)
Sun1^tm1Mhan mutation (1 available); any Sun1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:209347 )

abnormal male meiosis ( J:209347 )

cellular

abnormal chromosomal synapsis ( J:209347 )

abnormal male meiosis ( J:209347 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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