Mouse Genome Informatics
hm1
    Slc16a2tm1Dgen/Slc16a2tm1Dgen
either: (involves: C57BL/6N) or (involves: NMRI)
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively
• however, clearance from the blood and liver uptake is normal
• 34% reduction in serum T4 levels
• uptake of [125I]T3 in the brain is severely impaired
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively
• however, clearance from the blood and liver uptake is normal
• 203% increase in serum T3 levels

nervous system
N
• unlike in human patients no reduction in brain size or brain morphology was observed


Mouse Genome Informatics
ot2
    Slc16a2tm1Dgen/Y
either: (involves: C57BL/6N) or (involves: NMRI)
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively
• however, clearance from the blood and liver uptake is normal
• 34% reduction in serum T4 levels
• uptake of [125I]T3 in the brain is severely impaired
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively
• however, clearance from the blood and liver uptake is normal
• 203% increase in serum T3 levels

nervous system
N
• unlike in human patients no reduction in brain size or brain morphology was observed

Mouse Models of Human Disease
OMIM IDRef(s)
Allan-Herndon-Dudley Syndrome; AHDS 300523 J:120737