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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc16a2tm1Dgen
targeted mutation 1, Deltagen
MGI:3710233
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc16a2tm1Dgen/Slc16a2tm1Dgen either: (involves: C57BL/6N) or (involves: NMRI) MGI:3710594
ot2
Slc16a2tm1Dgen/Y either: (involves: C57BL/6N) or (involves: NMRI) MGI:3710595


Genotype
MGI:3710594
hm1
Allelic
Composition
Slc16a2tm1Dgen/Slc16a2tm1Dgen
Genetic
Background
either: (involves: C57BL/6N) or (involves: NMRI)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc16a2tm1Dgen mutation (0 available); any Slc16a2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• 34% reduction in serum T4 levels (J:120737)
• 34% reduction in serum T4 levels (J:120737)
• uptake of [125I]T3 in the brain is severely impaired (J:120737)
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• uptake of [125I]T3 in the brain is severely impaired (J:120737)
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• 203% increase in serum T3 levels (J:120737)
• 203% increase in serum T3 levels (J:120737)

nervous system
N
• unlike in human patients no reduction in brain size or brain morphology was observed (J:120737)
• unlike in human patients no reduction in brain size or brain morphology was observed (J:120737)




Genotype
MGI:3710595
ot2
Allelic
Composition
Slc16a2tm1Dgen/Y
Genetic
Background
either: (involves: C57BL/6N) or (involves: NMRI)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc16a2tm1Dgen mutation (0 available); any Slc16a2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• 34% reduction in serum T4 levels (J:120737)
• 34% reduction in serum T4 levels (J:120737)
• uptake of [125I]T3 in the brain is severely impaired (J:120737)
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• uptake of [125I]T3 in the brain is severely impaired (J:120737)
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• 203% increase in serum T3 levels (J:120737)
• 203% increase in serum T3 levels (J:120737)

nervous system
N
• unlike in human patients no reduction in brain size or brain morphology was observed (J:120737)
• unlike in human patients no reduction in brain size or brain morphology was observed (J:120737)

Mouse Models of Human Disease
OMIM ID Ref(s)
Allan-Herndon-Dudley Syndrome; AHDS 300523 J:120737





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory