Analysis Tools
vision/eye
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• filtration angle is severely malformed and ruptures in the tissue frequently occur, while in most sections, it is missing
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• status of canal is difficult to determine
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• filtration angle is without a trabecular meshwork
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• iris and ciliary body are replaced by single structure resembling a stunted iris
• zonular fibers reach up between posterior surface and lens
• histologically, the structure present does not resemble iris or ciliary body, with stromal and epithelial parts are compact, and structure lacks secretory apparatus, fenestrated capillaries, and musculature of the normal ciliary body
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• iris and ciliary body are replaced by single structure resembling a stunted iris
• anterior surface of structure is made up of stromal cells; histologically it does not resemble iris or ciliary body, with stromal and epithelial parts are compact and homogeneous lacking muscle cells, blood vessels, nerves and channels in extracellular space like a normal iris
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• stratification of cornea is less pronounced than in wild-type
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• endothelium does not develop normally
• inner corneal surface is covered by crowded and disorganized layer of cells resembling stromal cells of fused iris/ciliary body
• there is a high melanosome content in corneal endothelium; these often adhere to the 'iris/ciliary body stroma'
• mutants show high levels of N-cadherin in all mesenchyme facing the anterior chamber
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• stroma shows a reduction in number and density of collagen fibers
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• mice show fusion between cornea and small cataractic lens resulting from failure of lens vesicle to close and separate from surface ectoderm
• in adults, connection may be broken, leaving on central part of external corneal surface a deposit of tissue derived from interior of lens vesicle
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small lens
(
J:119940
)
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• lens is small and rudimentary
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cardiovascular system
