Analysis Tools
mortality/aging
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• embryos die by E11.5 as a result of placental and heart defects
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Allele Symbol Allele Name Allele ID |
Mapk14tm1.1Dvb targeted mutation 1.1, Dmitry V Bulavin MGI:3706998 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos die by E11.5 as a result of placental and heart defects
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• injection with the beta cell toxin streptozocin (STZ) results in lowered blood glucose levels in 4-6 month old mice (11 weeks post treatment) as compared to wild-type
• injection with the beta cell toxin streptozocin (STZ) results in lowered blood glucose levels in 9-14 month old mice (7 weeks post treatment) as compared to wild-type
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• islet cell proliferation is increased in 10-12 month old mutant mice at 3 and at 30 days post-STZ treatment as compared to wild-type
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• injection with the beta cell toxin streptozocin (STZ) results in lowered blood glucose levels in 4-6 month old mice (11 weeks post treatment) as compared to wild-type
• injection with the beta cell toxin streptozocin (STZ) results in lowered blood glucose levels in 9-14 month old mice (7 weeks post treatment) as compared to wild-type
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• islet cell proliferation is increased in 10-12 month old mutant mice at 3 and at 30 days post-STZ treatment as compared to wild-type
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• pancreatic islet proliferation is decreased in aged (22-24 month old) mice, but is similar to wild-type in young mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the median lifespan of 130 days
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• similar to mice carrying double Ppm1dtm1Lad allele without Mapk14tm1Dvb allele, based on increased median survival time, mice carrying single Mapk14tm1Dvb allele were considerably more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d+ allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• double mutant Ppm1dtm1Lad Mapk14tm1.1Dvb mice exhibit pancreatic islet proliferation similar to wild-type, correcting the phenotype observed in Ppm1dtm1Lad mutant mice
• double mutant Ppm1dtm1Lad Mapk14tm1.1Dvb mice do not exhibit impaired glucose tolerance, correcting the phenotype observed in Ppm1dtm1Lad/ mutant mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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