All Phenotypes Mmp13<tm1Jdar> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp13^tm1Jdar/Mmp13^tm1Jdar	B6.129S-Mmp13^tm1Jdar	MGI:4367722
hm2	Mmp13^tm1Jdar/Mmp13^tm1Jdar	involves: 129S/SvEv * C57BL/6J	MGI:3710132
cx3	Mmp13^tm1Jdar/Mmp13^tm1Jdar Mmp9^tm1Tvu/Mmp9^tm1Tvu	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:4367723

Allelic Composition	Mmp13^tm1Jdar/Mmp13^tm1Jdar
Genetic Background	B6.129S-Mmp13^tm1Jdar

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp13^tm1Jdar mutation (0 available); any Mmp13 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

delayed wound healing ( J:150790 )

• at days 3, 5, and 7, mice exhibit delayed wound closure with decreased vascular density at the wound compared with similarly treated wild-type mice

• during wound healing, mice exhibit reduced wound contraction and myofibroblast formation compared with similarly treated wild-type mice

• however, vascular density at the wound recovers by day 14

cellular

decreased cell proliferation ( J:150790 )

• in unstimulated or TGF-beta1-stimulated dermal fibroblasts compared with similarly treated wild-type fibroblasts

cardiovascular system

decreased angiogenesis ( J:150790 )

• vascular density is decreased at healing wounds compared to in similarly treated wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone healing ( J:120352 )

• in a stabilized tibia fracture, bony bridge formation fails to occur by post-fracture week (PFW) 3 unlike in control mice despite the progress of calcification

• calcified areas and bone mineral content (BMC) is reduced during the modeling phase (PFW2 to 3)

• however, there is no difference in calcified area and BMC in the remodeling stage (PFW4 to 10)

• at the fracture site, mice have a greater cartilage area to total callus area, and less bone area to total callus area ratio at PFW2 to 3 than controls

• the fracture site contains more hypertrophic chondrocytes (COL10A1+) than controls

• the fracture site had minimal cartilaginous breaks associated with capillary invasion and the chondroclasts are not attached to the cartilage matrix

abnormal cartilage development ( J:120352 )

• when chondrocytes are cultured in 3D collagen gel pellets, contraction of the gel and cartilage matrix synthesis is less on day 7 than in wild-type

cardiovascular system

decreased angiogenesis ( J:120352 )

• after 1 week of chondrocytes being co-cultured with HUVEC, there is limited vascular sprouting as compared to wild-type

homeostasis/metabolism

abnormal bone healing ( J:120352 )

• in a stabilized tibia fracture, bony bridge formation fails to occur by post-fracture week (PFW) 3 unlike in control mice despite the progress of calcification

• calcified areas and bone mineral content (BMC) is reduced during the modeling phase (PFW2 to 3)

• however, there is no difference in calcified area and BMC in the remodeling stage (PFW4 to 10)

• at the fracture site, mice have a greater cartilage area to total callus area, and less bone area to total callus area ratio at PFW2 to 3 than controls

• the fracture site contains more hypertrophic chondrocytes (COL10A1+) than controls

• the fracture site had minimal cartilaginous breaks associated with capillary invasion and the chondroclasts are not attached to the cartilage matrix

Allelic Composition	Mmp13^tm1Jdar/Mmp13^tm1Jdar Mmp9^tm1Tvu/Mmp9^tm1Tvu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp13^tm1Jdar mutation (0 available); any Mmp13 mutation (33 available)
Mmp9^tm1Tvu mutation (2 available); any Mmp9 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

delayed wound healing ( J:150790 )

• at days 3, 5, and 7, mice exhibit delayed wound closure with decreased vascular density at the wound compared with similarly treated wild-type mice

• during wound healing, mice exhibit reduced wound contraction and myofibroblast formation compared with similarly treated wild-type mice

• however, vascular density at the wound recovers by day 14

cellular

decreased cell proliferation ( J:150790 )

• in unstimulated or TGF-beta1-stimulated dermal fibroblasts compared with similarly treated wild-type fibroblasts

skeleton

abnormal epiphyseal plate morphology ( J:150790 )

growth/size/body

postnatal growth retardation ( J:150790 )

cardiovascular system

decreased angiogenesis ( J:150790 )

• vascular density is decreased at healing wounds compared to in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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