Mouse Genome Informatics
cx1
    Cd4tm1Litt/Cd4tm1Litt
Tg(Cd4-CD4)2362Litt/0

involves: 129S2/SvPas * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• the human CD4 transgene rescues the phenotype associated with Cd4tm1Litt homozygotes (J:50435)


Mouse Genome Informatics
cx2
    Tg(Cd4-CD4)2362Litt/0
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0

involves: C57BL/6 * DBA/2 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease
• onset, clinical manifestations and course of disease are highly variable
• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects
• drowsy
• staggering gait

nervous system
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease
OMIM IDRef(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:134764


Mouse Genome Informatics
tg3
    Tg(Cd4-CD4)2362Litt/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• CD4 T cells express both the mouse and human CD4 without any adverse effects on phenotype (J:50435)