About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cd4-CD4)2362Litt
transgene insertion 2362, Dan R Littman
MGI:3702083
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Cd4tm1Litt/Cd4tm1Litt
Tg(Cd4-CD4)2362Litt/0
involves: 129S2/SvPas * C57BL/6 * SJL MGI:3800657
cx2
Tg(Cd4-CD4)2362Litt/0
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
involves: C57BL/6 * DBA/2 * SJL MGI:5429704
tg3
Tg(Cd4-CD4)2362Litt/0 involves: C57BL/6 * SJL MGI:3800658


Genotype
MGI:3800657
cx1
Allelic
Composition
Cd4tm1Litt/Cd4tm1Litt
Tg(Cd4-CD4)2362Litt/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Litt mutation (4 available); any Cd4 mutation (52 available)
Tg(Cd4-CD4)2362Litt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• the human CD4 transgene rescues the phenotype associated with Cd4tm1Litt homozygotes




Genotype
MGI:5429704
cx2
Allelic
Composition
Tg(Cd4-CD4)2362Litt/0
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
Genetic
Background
involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-CD4)2362Litt mutation (2 available)
Tg(HLA-DR2)#Lfug mutation (0 available)
Tg(TCROb.1A12)#Lfug mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease
• onset, clinical manifestations and course of disease are highly variable
• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects
• drowsy
• staggering gait

nervous system
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:134764




Genotype
MGI:3800658
tg3
Allelic
Composition
Tg(Cd4-CD4)2362Litt/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-CD4)2362Litt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• CD4 T cells express both the mouse and human CD4 without any adverse effects on phenotype





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory