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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad9tm1Rob
targeted mutation 1, Elizabeth J Robertson
MGI:3701868
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad9tm1Rob/Smad9tm1Rob involves: 129S/SvEv MGI:3702562
cx2
 		Ark2cGt(P9-3F)Sor/Ark2c+
Smad9tm1Rob/Smad9tm1Rob
Tg(Hlxb9-GFP)1Tmj/0 		involves: 129S/SvEv * C57BL/6 * CBA MGI:5516590


Genotype
MGI:3702562
hm1
Allelic
Composition		 Smad9tm1Rob/Smad9tm1Rob
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad9tm1Rob mutation (2 available); any Smad9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:119296 )
• homozygous mice are healthy with no apparent abnormalities




Genotype
MGI:5516590
cx2
Allelic
Composition		 Ark2cGt(P9-3F)Sor/Ark2c+
Smad9tm1Rob/Smad9tm1Rob
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ark2cGt(P9-3F)Sor mutation (0 available); any Ark2c mutation (11 available)
Smad9tm1Rob mutation (2 available); any Smad9 mutation (32 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:198828 )
• fewer than expected mice survive prior to weaning
prenatal lethality, incomplete penetrance ( J:198828 )
• fewer than expected mice are born

muscle
skeletal muscle atrophy ( J:198828 )
• unilateral penetrance in the muscles controlling the digits and wrist

behavior/neurological
decreased grip strength ( J:198828 )
• some mice exhibit reduced hang time from a cage lid compared with wild-type mice

nervous system
abnormal motor neuron innervation pattern ( J:198828 )
• reduction or loss of the most distal innervation in the forelimbs

skeleton
abnormal joint mobility ( J:198828 )
• as in Rnf165 homozygotes

limbs/digits/tail
abnormal forelimb morphology ( J:198828 )
• as in Rnf165 homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory