Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation
(3 available);
any
Apobec3 mutation
(125 available)
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immune system
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• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is almost two orders of magnitude lower than in controls
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• 16-week old mice mice infected with Friend virus have much higher virus counts in their blood 8 days later as C57BL/6 controls
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hematopoietic system
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• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is almost two orders of magnitude lower than in controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation
(3 available);
any
Apobec3 mutation
(125 available)
|
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immune system
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• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is almost two orders of magnitude lower than in controls
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• 16-week old mice mice infected with Friend virus have 6.2 times as much virus in their blood 8 days later as C57BL/6 controls
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hematopoietic system
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• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is almost two orders of magnitude lower than in controls
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation
(3 available);
any
Apobec3 mutation
(125 available)
|
|
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immune system
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• mice infected subcutaneously with MMTV(RIII) display a more rapid and extensive spread of infection compared to wild-type mice
• these mice also display increases in activated B and T cells in the draining and non-draining lymph nodes
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immune system
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• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls
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hematopoietic system
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• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls
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mortality/aging
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• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls
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immune system
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• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls
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• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls
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• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls
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hematopoietic system
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• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls
|