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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spry4tm1Ayos
targeted mutation 1, Akihiko Yoshimura
MGI:3699499
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spry4tm1Ayos/Spry4tm1Ayos B6.Cg-Spry4tm1Ayos MGI:3700034
cx2
Spry2tm1Ayos/Spry2+
Spry4tm1Ayos/Spry4tm1Ayos
involves: 129 * C57BL/6J MGI:3700035
cx3
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4+
involves: 129 * C57BL/6J MGI:3700036
cx4
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4tm1Ayos
involves: 129 * C57BL/6J MGI:3700037


Genotype
MGI:3700034
hm1
Allelic
Composition
Spry4tm1Ayos/Spry4tm1Ayos
Genetic
Background
B6.Cg-Spry4tm1Ayos
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry4tm1Ayos mutation (1 available); any Spry4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer homozygotes are seen than expected at P7, although those that survive live to at least 12 months of age

growth/size/body
• 3 of 14 homozygotes show increased incisor size
• postnatal growth is reduced

craniofacial
• 4 of 7 E13.5-E18.5 embryos show mandible defects
• mutants that die shortly after birth exhibit mandible defects
• 3 of 14 homozygotes show increased incisor size
• 3 of 14 show malocclusion

limbs/digits/tail
• polysyndactyly is almost fully penetrative and characterized by fusion and duplication of digits at the forelimbs

skeleton
• 4 of 7 E13.5-E18.5 embryos show mandible defects
• mutants that die shortly after birth exhibit mandible defects
• 3 of 14 homozygotes show increased incisor size
• 3 of 14 show malocclusion

respiratory system
N
• homozygotes exhibit normal lung branching




Genotype
MGI:3700035
cx2
Allelic
Composition
Spry2tm1Ayos/Spry2+
Spry4tm1Ayos/Spry4tm1Ayos
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (16 available)
Spry4tm1Ayos mutation (1 available); any Spry4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are rarely born
• homozygotes that are born appear sick and most die within a few weeks of birth for unknown reasons

growth/size/body




Genotype
MGI:3700036
cx3
Allelic
Composition
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4+
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (16 available)
Spry4tm1Ayos mutation (1 available); any Spry4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3700037
cx4
Allelic
Composition
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4tm1Ayos
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (16 available)
Spry4tm1Ayos mutation (1 available); any Spry4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

vision/eye

craniofacial
• craniofacial abnormalities

limbs/digits/tail
• limb abnormalities

nervous system
• severe truncation of the forebrain and cephalic neural crest-derived head tissues
• alobar brain development and cyclopia resemble holoprosencephaly

respiratory system
• exhibit abnormalities of the lung pattern and epithelial branching

Mouse Models of Human Disease
OMIM ID Ref(s)
Apert Syndrome 101200 J:116506





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory