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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acvr2btm1.1Spo
targeted mutation 1.1, S Paul Oh
MGI:3697600
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Acvr2btm1.1Spo/Acvr2btm1.1Spo involves: 129S4/SvJae * FVB/N MGI:3697595
cx2
 		Acvr2atm1Hsch/Acvr2a+
Acvr2btm1.1Spo/Acvr2btm1.1Spo 		involves: 129S1/Sv * 129S4/SvJae * FVB/N MGI:3697597
cx3
 		Acvr2atm1Hsch/Acvr2atm1Hsch
Acvr2btm1.1Spo/Acvr2btm1.1Spo 		involves: 129S1/Sv * 129S4/SvJae * FVB/N MGI:3697598


Genotype
MGI:3697595
hm1
Allelic
Composition		 Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2btm1.1Spo mutation (0 available); any Acvr2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
vertebral transformation ( J:114533 )
• only 3 of 21 exhibit vertebral transformation, a significant decrease in the defects seen in Acvr2btm1Spo homozygotes




Genotype
MGI:3697597
cx2
Allelic
Composition		 Acvr2atm1Hsch/Acvr2a+
Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2atm1Hsch mutation (0 available); any Acvr2a mutation (38 available)
Acvr2btm1.1Spo mutation (0 available); any Acvr2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
lumbar vertebral transformation ( J:114533 )
• 6 of 16 exhibit transformation of the 21st vertebra into the 14th thoracic vertebra

embryo
abnormal left-right axis patterning ( J:114533 )
• 12 of 13 show effects associated with left-right asymmetry such as right pulmonary isomerism and transposition of great arteries

cardiovascular system

respiratory system

growth/size/body
right pulmonary isomerism ( J:114533 )




Genotype
MGI:3697598
cx3
Allelic
Composition		 Acvr2atm1Hsch/Acvr2atm1Hsch
Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2atm1Hsch mutation (0 available); any Acvr2a mutation (38 available)
Acvr2btm1.1Spo mutation (0 available); any Acvr2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth arrest ( J:114533 )
• development is arrested at the gastrulation stage (E8.5)
abnormal embryonic tissue morphology ( J:114533 )
• the embryonic tissues grow outside of the yolk sac
embryonic-extraembryonic boundary constriction ( J:114533 )
• exhibit constrictions at the junction between the extraembryonic and embryonic regions at E7.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory