Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp5tm1Shwl mutation
(0 available);
any
Sfrp5 mutation
(25 available)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp5tm1Shwl mutation
(0 available);
any
Sfrp5 mutation
(25 available)
|
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normal phenotype
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• viable and fertile with normal forgut morphogenesis, liver bud development, axis formation, anterior visceral endoderm development, and primitive streak formation
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation
(0 available);
any
Dkk1 mutation
(17 available)
Sfrp5tm1Shwl mutation
(0 available);
any
Sfrp5 mutation
(25 available)
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mortality/aging
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• no viable double homozygotes are found
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embryo
N |
• location of the anterior visceral endoderm and primitive streak morphology are similar to controls
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growth/size/body
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• at E17.5 9 of 18 mice lack anterior head structures
• this is not significantly different from Dkk1 single homozygotes on the same genetic background
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