Mouse Genome Informatics
cx1
    Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months

other phenotype
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months


Mouse Genome Informatics
cx2
    Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months

other phenotype
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months


Mouse Genome Informatics
cx3
    Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0

involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

other phenotype
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged


Mouse Genome Informatics
tg4
    Tg(PSEN1H163R)G9Btla/0
involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• lower levels of Abeta1-42 amyloid peptide accumulate compared to double transgenic mice

other phenotype
• lower levels of Abeta1-42 amyloid peptide accumulate compared to double transgenic mice

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 3 607822 J:58050
Alzheimer Disease; AD 104300 J:58050