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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(PSEN1H163R)G9Btla
transgene insertion G9, Bruce Lamb
MGI:3693364
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3693489
cx2
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3693490
cx3
Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0
involves: 129S4/SvJae MGI:3693492
tg4
Tg(PSEN1H163R)G9Btla/0 involves: 129S4/SvJae MGI:3693491


Genotype
MGI:3693489
cx1
Allelic
Composition
Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (0 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice (J:58050)
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months (J:58050)
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice (J:58050)
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months (J:58050)

homeostasis/metabolism
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice (J:58050)
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months (J:58050)
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice (J:58050)
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months (J:58050)




Genotype
MGI:3693490
cx2
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (0 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months (J:58050)
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months (J:58050)

homeostasis/metabolism
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months (J:58050)
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months (J:58050)




Genotype
MGI:3693492
cx3
Allelic
Composition
Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwLon)96Btla mutation (0 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged (J:58050)
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged (J:58050)

homeostasis/metabolism
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged (J:58050)
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged (J:58050)




Genotype
MGI:3693491
tg4
Allelic
Composition
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• lower levels of Abeta1-42 amyloid peptide accumulate compared to double transgenic mice (J:58050)
• lower levels of Abeta1-42 amyloid peptide accumulate compared to double transgenic mice (J:58050)

homeostasis/metabolism
• lower levels of Abeta1-42 amyloid peptide accumulate compared to double transgenic mice (J:58050)
• lower levels of Abeta1-42 amyloid peptide accumulate compared to double transgenic mice (J:58050)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:58050
Alzheimer Disease; AD 104300 J:58050





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory