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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ybx3tm1Ley
targeted mutation 1, Timothy J Ley
MGI:3693011
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ybx3tm1Ley/Ybx3tm1Ley involves: 129X1/SvJ * C57BL/6 MGI:3696388
cx2
 		Ybx3tm1Ley/Ybx3tm1Ley
Ybx1tm1Ley/Ybx1tm1Ley 		involves: 129X1/SvJ * C57BL/6 MGI:3696389
cx3
 		Ybx3tm1Ley/Ybx3+
Ybx1tm1Ley/Ybx1tm1Ley 		involves: 129X1/SvJ * C57BL/6 MGI:3696390


Genotype
MGI:3696388
hm1
Allelic
Composition		 Ybx3tm1Ley/Ybx3tm1Ley
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ybx3tm1Ley mutation (0 available); any Ybx3 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
seminiferous tubule degeneration ( J:115970 )
• progressive vacuolization is seen in the tubules beginning at 3 months of age
• vacuolization occurs in spermatocytes
small testis ( J:115970 )
• slightly but significantly smaller at 2, 3, and 5 months of age
abnormal spermatogenesis ( J:115970 )
• increased apoptosis occurs in meiotic and post-meiotic spermatocytes during mid to late spermatogenesis
oligozoospermia ( J:115970 )
• seen at 2 to 12 months of age
male infertility ( J:115970 )
• 3 of 6 males were infertile
• however, all females were fertile

endocrine/exocrine glands
seminiferous tubule degeneration ( J:115970 )
• progressive vacuolization is seen in the tubules beginning at 3 months of age
• vacuolization occurs in spermatocytes
small testis ( J:115970 )
• slightly but significantly smaller at 2, 3, and 5 months of age

cellular
oligozoospermia ( J:115970 )
• seen at 2 to 12 months of age




Genotype
MGI:3696389
cx2
Allelic
Composition		 Ybx3tm1Ley/Ybx3tm1Ley
Ybx1tm1Ley/Ybx1tm1Ley
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ybx1tm1Ley mutation (0 available); any Ybx1 mutation (18 available)
Ybx3tm1Ley mutation (0 available); any Ybx3 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:115970 )
• almost all die between E8.5 and E11.5




Genotype
MGI:3696390
cx3
Allelic
Composition		 Ybx3tm1Ley/Ybx3+
Ybx1tm1Ley/Ybx1tm1Ley
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ybx1tm1Ley mutation (0 available); any Ybx1 mutation (18 available)
Ybx3tm1Ley mutation (0 available); any Ybx3 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:115970 )
• almost all alive at E16.5 but absent at weaning

growth/size/body
decreased embryo size ( J:115970 )
• in a small proportion of mice at E13.5
decreased fetal size ( J:115970 )
• in a small proportion of mice at E13.5 - E16.5

nervous system
exencephaly ( J:115970 )
• in a small proportion of mice at E13.5 - E16.5

embryo
decreased embryo size ( J:115970 )
• in a small proportion of mice at E13.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory