All Phenotypes Fcgr1<tm1Jgjw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fcgr1^tm1Jgjw
targeted mutation 1, Jan G J van de Winkel
MGI:3664782

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fcgr1^tm1Jgjw/Fcgr1^tm1Jgjw	involves: 129 * C57BL/6	MGI:3701432

Allelic Composition	Fcgr1^tm1Jgjw/Fcgr1^tm1Jgjw
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr1^tm1Jgjw mutation (0 available); any Fcgr1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal dendritic cell differentiation ( J:112436 )

• OVA-ICs do not induce maturation of BM-DCs from mutants

immune system

abnormal dendritic cell differentiation ( J:112436 )

• OVA-ICs do not induce maturation of BM-DCs from mutants

abnormal dendritic cell antigen presentation ( J:112436 )

• mutant bone marrow-derived dendritic cells (BM-DC) treated with ovalbumin-immune complexes (OVA-IC) do not present the MHC class I-restricted epitope after OVA-IC internalization

cellular

abnormal dendritic cell differentiation ( J:112436 )

• OVA-ICs do not induce maturation of BM-DCs from mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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