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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx21tm1Srnr
targeted mutation 1, Steven L Reiner
MGI:3664621
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbx21tm1Srnr/Tbx21tm1Srnr involves: C57BL/6 MGI:3687960
ht2
 		Tbx21tm1Srnr/Tbx21+ involves: C57BL/6 MGI:3687961
cn3
 		Eomestm1Srnr/Eomestm1Srnr
Tbx21tm1Srnr/Tbx21tm1Srnr
Tg(Cd4-cre)1Cwi/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3804634
cx4
 		Eomestm1Apr/Eomes+
Tbx21tm1Srnr/Tbx21tm1Srnr 		involves: C57BL/6 MGI:3687959


Genotype
MGI:3687960
hm1
Allelic
Composition		 Tbx21tm1Srnr/Tbx21tm1Srnr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21tm1Srnr mutation (0 available); any Tbx21 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:112679 )
• lymphoid tissues considerably depleted of NK-T cells

hematopoietic system
decreased NK T cell number ( J:112679 )
• lymphoid tissues considerably depleted of NK-T cells




Genotype
MGI:3687961
ht2
Allelic
Composition		 Tbx21tm1Srnr/Tbx21+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21tm1Srnr mutation (0 available); any Tbx21 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:112679 )
• partial loss of natural killer cells
absent NK T cells ( J:112679 )
• lack most NK-T cells

hematopoietic system
decreased NK cell number ( J:112679 )
• partial loss of natural killer cells
absent NK T cells ( J:112679 )
• lack most NK-T cells




Genotype
MGI:3804634
cn3
Allelic
Composition		 Eomestm1Srnr/Eomestm1Srnr
Tbx21tm1Srnr/Tbx21tm1Srnr
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1Srnr mutation (1 available); any Eomes mutation (41 available)
Tbx21tm1Srnr mutation (0 available); any Tbx21 mutation (36 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:137655 )
• impaired cytotoxic CD8+ T cell differentiation following viral infection
• following viral infection, differentiation is skewed exclusively toward the Type 17 fate
decreased CD8-positive, alpha-beta T cell number ( J:137655 )
• defect in accumulation of CD8+ T cells following viral infection
decreased memory T cell number ( J:137655 )
• deficiency in memory-phenotype CD8+ T cells
abnormal leukocyte physiology ( J:137655 )
• CD8+ T cells have a severe defect in cytotoxic gene expression in response to viral peptide stimulation even when cellularity is normalized
abnormal interleukin level ( J:137655 )
• increase in IL17 expression in CD8+ T cells in response to stimulation with viral derived peptides
increased susceptibility to Riboviria infection ( J:137655 )
• persistent high titers of lymphocyte choriomeningitis virus
• progressive weight loss, not seen in controls, begins about 1 week after infection and is accompanied by extensive organ pathology and excessive neutrophil response
• depletion of CD8+ T cells prevents viral induced wasting, neutrophilia, and organ pathology

homeostasis/metabolism
abnormal interleukin level ( J:137655 )
• increase in IL17 expression in CD8+ T cells in response to stimulation with viral derived peptides

hematopoietic system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:137655 )
• impaired cytotoxic CD8+ T cell differentiation following viral infection
• following viral infection, differentiation is skewed exclusively toward the Type 17 fate
decreased CD8-positive, alpha-beta T cell number ( J:137655 )
• defect in accumulation of CD8+ T cells following viral infection
decreased memory T cell number ( J:137655 )
• deficiency in memory-phenotype CD8+ T cells
abnormal leukocyte physiology ( J:137655 )
• CD8+ T cells have a severe defect in cytotoxic gene expression in response to viral peptide stimulation even when cellularity is normalized




Genotype
MGI:3687959
cx4
Allelic
Composition		 Eomestm1Apr/Eomes+
Tbx21tm1Srnr/Tbx21tm1Srnr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1Apr mutation (0 available); any Eomes mutation (41 available)
Tbx21tm1Srnr mutation (0 available); any Tbx21 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:112679 )
• partial loss of natural killer cells
decreased NK T cell number ( J:112679 )
• lymphoid tissues considerably depleted of NK-T cells
decreased memory T cell number ( J:112679 )
• depleted CD8+ memory T cells
decreased interferon-gamma secretion ( J:112679 )
• defective Ifng production by CD8+ cells in vitro

hematopoietic system
decreased NK cell number ( J:112679 )
• partial loss of natural killer cells
decreased NK T cell number ( J:112679 )
• lymphoid tissues considerably depleted of NK-T cells
decreased memory T cell number ( J:112679 )
• depleted CD8+ memory T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory