Phenotypes associated with this allele

• Allele Symbol: Ifih1^tm1.1Cln
• Allele Name: targeted mutation 1.1, Marco Colonna
• Allele ID: MGI:3663677
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifih1^tm1.1Cln/Ifih1^tm1.1Cln	involves: 129X1/SvJ	MGI:6822329
hm2	Ifih1^tm1.1Cln/Ifih1^tm1.1Cln	involves: 129X1/SvJ * C57BL/6	MGI:3712984
cn3	Adar^em1Stsn/Adar^tm1.1Phs Ifih1^tm1.1Cln/Ifih1^tm1.1Cln Meox2^tm1(cre)Sor/Meox2^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:7281845
cx4	Adar^em1Stsn/Adar^tm1Olds Ifih1^tm1.1Cln/Ifih1^tm1.1Cln	involves: 129S/SvEv * 129X1/SvJ * C57BL/6J	MGI:7281844

Genotype
MGI:6822329

hm1

• Allelic Composition: Ifih1^tm1.1Cln/Ifih1^tm1.1Cln
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interferon-beta secretion ( J:240099 )

• induction of IFN-beta mRNA expression in bone marrow derived macrophages (BMDMs) is abrogated following infection with encephalomyocarditis virus (EMCV), or after stimulation with HMW poly I:C or EMCV-RNA

• in contrast, IFN-beta mRNA expression in BMDMs is normal following infection with vesicular stomatitis virus (VSV, Indiana strain), or after stimulation with LMW poly I:C or VSV-RNA

Genotype
MGI:3712984

hm2

• Allelic Composition: Ifih1^tm1.1Cln/Ifih1^tm1.1Cln
• Genetic Background: involves: 129X1/SvJ * C57BL/6

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:110201 )

• mice die sooner than wild-type following encephalomyocarditis virus infection

immune system

abnormal cytokine secretion ( J:110201 )

• both naked and transfected polyI:C induced cytokine secretion is reduced 2- to 3-fold

• IFN-alpha, IL-6 and MCP-1 secretion in response to encephalomyocarditis virus infection (EMCV) is abrogated

decreased interferon-alpha secretion ( J:110201 )

• IFN-alpha production following polyI:C induction is abrogated

• IFN-alpha induction by recombinant influenza A with the R38A NS1 mutation, West Nile wirus, Sindbus virus and herpes simplex virus-1 is reduced 2-fold

decreased interleukin-6 secretion ( J:110201 )

• polyI:C induction of IL-6 is reduced in a limited fashion

increased susceptibility to Picornaviridae infection ( J:110201 )

• following encephalomyocarditis virus infection (EMCV), mice develop symptoms of hindlimb paralysis earlier (at 24 to 72 hours) and die sooner

• IFN-alpha, IL-6 and MCP-1 secretion in response to EMCV is abrogated

• however, response to murine cytomegalovirus (MCMV) and reovirus is normal

Genotype
MGI:7281845

cn3

• Allelic Composition: Adar^em1Stsn/Adar^tm1.1Phs; Ifih1^tm1.1Cln/Ifih1^tm1.1Cln; Meox2^tm1(cre)Sor/Meox2⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

growth/size/body

growth/size/body region phenotype ( J:308678 )

N • normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

N • normal survival

Genotype
MGI:7281844

cx4

• Allelic Composition: Adar^em1Stsn/Adar^tm1Olds; Ifih1^tm1.1Cln/Ifih1^tm1.1Cln
• Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

growth/size/body

growth/size/body region phenotype ( J:308678 )

N • normal weight, weight gain and growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

N • normal expression of interferon-stimulated genes in cerebellum, kidney and liver

N • normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging

mortality/aging ( J:308678 )

N • normal survival