Phenotypes associated with this allele
Allelic
Composition |
Vdrtm2Ska/Vdrtm2Ska
|
|
Genetic
Background |
involves: C57BL/6NCrlj * CBA/JNCrlj |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vdrtm2Ska mutation
(1 available);
any
Vdr mutation
(35 available)
|
|
|
hearing/vestibular/ear
|
|
• topical application of MC903 a low calcemic analog of vitamin D to the ears results in obvious inflammation by day 17
|
immune system
|
|
• topical application of MC903 a low calcemic analog of vitamin D to the ears results in obvious inflammation by day 17
|
integument
|
|
• massive dermal infiltrate of eosinophils , CD4+ T cells, dendritic cells and mast cells is detected in ears of MC903-treated mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Ipc mutation
(0 available)
Vdrtm2Ska mutation
(1 available);
any
Vdr mutation
(35 available)
|
|
|
integument
|
N |
• topical application of MC903 a low calcemic analog of vitamin D to the ears does not cause obvious inflammation of the skin compared to Vdrtm1Pcn homozygous controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col1a1-cre)1Kry mutation
(2 available)
Vdrtm2Ska mutation
(1 available);
any
Vdr mutation
(35 available)
|
|
|
skeleton
|
N |
• osteoblasts exhibit normal mineral metabolism
• cortical thickness in the femur is normal at 16 weeks
|
|
|
• at 16 weeks
• however, trabecular bone volume of the distal femoral metaphysis at 4 and 9 weeks is normal
|
homeostasis/metabolism
cellular
immune system
hematopoietic system
Analysis Tools