Phenotypes associated with this allele

• Allele Symbol: Matn3^tm1Brd
• Allele Name: targeted mutation 1, Allan Bradley
• Allele ID: MGI:3663272
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Matn3^tm1Brd/Matn3^tm1Brd	involves: 129S7/SvEvBrd * C57BL/6	MGI:3687322

Genotype
MGI:3687322

hm1

• Allelic Composition: Matn3^tm1Brd/Matn3^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

osteoarthritis ( J:112002 )

• rare in knee cartilage at 18 weeks of age

• present in 100% of year old mice as opposed to 45% of controls who also suffer from less severe symptoms

abnormal long bone epiphyseal plate proliferative zone ( J:112002 )

• hypertrophic zone of the proximal growth plate of tibia expanded 47% relative to controls at E16.5 and E17.5

• expansion attenuated during perinatal development and becomes normal in newborns

• chondrocytes in proximal growth plate exit the cell cycle early

• at E16.5, chondrocytes undergo premature differentiation to hypertrophic stage

increased bone mass ( J:112002 )

• whole body bone mass density measurements significantly elevated by 18 weeks of age

• bone mass density measurements for the knee joint are elevated by 7 weeks of age

immune system

osteoarthritis ( J:112002 )

• rare in knee cartilage at 18 weeks of age

• present in 100% of year old mice as opposed to 45% of controls who also suffer from less severe symptoms

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoarthritis		DOID:8398		J:112002