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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*G37R)1Dwc
transgene insertion 1, Don W Cleveland
MGI:3629226
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Isl1tm1(cre)Tmj/Isl1+
Tg(SOD1*G37R)1Dwc/0
involves: 129X1/SvJ * C57BL/6 MGI:3629232
cn2
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
involves: C57BL/6 * CBA MGI:3629233
tg3
Tg(SOD1*G37R)1Dwc/0 involves: C57BL/6 MGI:3629231


Genotype
MGI:3629232
cn1
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (20 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• overall survival is extended 64 days

nervous system
• in transgenic mice expressing a motorneuron specific Cre, disease onset is delayed 18 days
• progression from onset through early disease is delayed 31 days
• later disease progression is slowed with an average extension of 15 days

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 1 DOID:0060193 OMIM:105400
J:109131




Genotype
MGI:3629233
cn2
Allelic
Composition
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ITGAM-cre)2781Gkl mutation (1 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• expression of Cre in microglia extends the lifespan of mutant SOD1-expressing mice by an average of 99 days compared to non-ITGAM-cre expressing mice

nervous system
• progression of later stage disease is slowed by an average of 75 days in mice expressing both transgenes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 1 DOID:0060193 OMIM:105400
J:109131




Genotype
MGI:3629231
tg3
Allelic
Composition
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• transgenic mice develop end-stage disease by 8.5-11 months of age

growth/size/body
• mice display weight loss from denervation induced muscle atrophy

nervous system
• mice in end-stage disease display 55% spinal motor neuron death
• mice develop fatal progressive motorneuron disease





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory