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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*G37R)1Dwc
transgene insertion 1, Don W Cleveland
MGI:3629226
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Isl1tm1(cre)Tmj/Isl1+
Tg(SOD1*G37R)1Dwc/0
involves: 129X1/SvJ * C57BL/6 MGI:3629232
cn2
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
involves: C57BL/6 * CBA MGI:3629233
tg3
Tg(SOD1*G37R)1Dwc/0 involves: C57BL/6 MGI:3629231


Genotype
MGI:3629232
cn1
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• overall survival is extended 64 days

nervous system
• in transgenic mice expressing a motorneuron specific Cre, disease onset is delayed 18 days
• progression from onset through early disease is delayed 31 days
• later disease progression is slowed with an average extension of 15 days

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109131




Genotype
MGI:3629233
cn2
Allelic
Composition
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ITGAM-cre)2781Gkl mutation (1 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• expression of Cre in microglia extends the lifespan of mutant SOD1-expressing mice by an average of 99 days compared to non-ITGAM-cre expressing mice

nervous system
• progression of later stage disease is slowed by an average of 75 days in mice expressing both transgenes

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109131




Genotype
MGI:3629231
tg3
Allelic
Composition
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• transgenic mice develop end-stage disease by 8.5-11 months of age

growth/size/body
• mice display weight loss from denervation induced muscle atrophy

nervous system
• mice in end-stage disease display 55% spinal motor neuron death
• mice develop fatal progressive motorneuron disease





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory