Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm3(AR)Dmr mutation
(1 available);
any
Ar mutation
(22 available)
Tg(TRAMP)8247Ng mutation
(1 available)
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neoplasm
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• at 29 weeks of age, only 28% of transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice: shorter Q tract length confers some protection from prostate cancer
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Allelic Composition |
Artm3(AR)Dmr/Y
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Genetic Background |
involves: 129S1/Sv * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm3(AR)Dmr mutation
(1 available);
any
Ar mutation
(22 available)
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adipose tissue
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• 24-month old males showed a trend toward higher percentage of body fat relative to wild-type or Artm1(AR)Dmr males
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growth/size/body
N |
• hemizygous mutant males are of normal size and body weight at 22-23 months of age
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• hemizygous mutant males display a trend toward higher body weights than wild-type or Artm1(AR)Dmr males
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reproductive system
N |
• hemizygous mutant males exhibit normal fertility and normal testes
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behavior/neurological
N |
• hemizygous mutant males display normal forelimb grip-strength with no evidence of neuromuscular weakness at 22-23 months of age
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muscle
N |
• at 3-5 months of age, hemizygous mutant males display normal skeletal muscle morphology, with no evidence of neurogenic atrophy or myopathy in hind-limb muscles
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nervous system
N |
• aged hemizygous mutant males show normal spinal cord morphology
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