Mouse Genome Informatics
cx1
     Artm3(AR)Dmr/Y
Tg(TRAMP)8247Ng/0
involves: 129S1/Sv * C57BL/6
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
tumorigenesis
decreased tumor incidence ( J:108849 )
• at 29 weeks of age, only 28% of transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice: shorter Q tract length confers some protection from prostate cancer (J:108849)

Mouse Models of Human Disease
 OMIM IDRef(s)
Prostate Cancer 176807 J:108849


Mouse Genome Informatics
ot2
     Artm3(AR)Dmr/Y
involves: 129S1/Sv * C57BL/6J
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
adipose tissue
increased percent body fat ( J:108849 )
• 24-month old males showed a trend toward higher percentage of body fat relative to wild-type or Artm1(AR)Dmr males (J:108849)

growth/size
growth/size phenotype ( J:114552 )
N
• hemizygous mutant males are of normal size and body weight at 22-23 months of age (J:114552)
increased body weight ( J:108849 )
• hemizygous mutant males display a trend toward higher body weights than wild-type or Artm1(AR)Dmr males (J:108849)

reproductive system
reproductive system phenotype ( J:104360 )
N
• hemizygous mutant males exhibit normal fertility and normal testes (J:104360)

behavior/neurological
behavior/neurological phenotype ( J:114552 )
N
• hemizygous mutant males display normal forelimb grip-strength with no evidence of neuromuscular weakness at 22-23 months of age (J:114552)

muscle
muscle phenotype ( J:114552 )
N
• at 3-5 months of age, hemizygous mutant males display normal skeletal muscle morphology, with no evidence of neurogenic atrophy or myopathy in hind-limb muscles (J:114552)

nervous system
nervous system phenotype ( J:114552 )
N
• aged hemizygous mutant males show normal spinal cord morphology (J:114552)