Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
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mortality/aging
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• no homozygous deleted mice recovered at birth; stage of lethality not specified
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
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nervous system
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• abnormal distribution of interneurons indicates a defect in migration
• apparent delay in the migration of dentate precursors to the dentate gyrus subpial zone
• decrease in the chemotactic response to CXCL12 of cultured dentate gyrus derived cells
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• decrease in proliferation of granule cells in the hippocampal dentate gyrus but not in the dentate ventricular zone or the fimbrio-dentate junction at E18.5
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• distribution is altered at E18.5 with fewer found in the marginal zone and more found in the deep cortical plate
• decrease in the number PV+ interneurons in the medial prefrontal cortex at 1 month of age
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• decrease in volume at P0
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• however, basal synaptic transmission is normal
• in mature (16-20 weeks of age) but not in young (8-10 weeks of age) mice
• increased by over 200% in CA3 and CA1 pyramidal neurons in mature mice
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cellular
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• abnormal distribution of interneurons indicates a defect in migration
• apparent delay in the migration of dentate precursors to the dentate gyrus subpial zone
• decrease in the chemotactic response to CXCL12 of cultured dentate gyrus derived cells
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• decrease in proliferation of granule cells in the hippocampal dentate gyrus but not in the dentate ventricular zone or the fimbrio-dentate junction at E18.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
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nervous system
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• PPI is significantly impaired; mice have reduced PPI
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
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reproductive system
cardiovascular system
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• hypoplastic at E10.5
• however, arteries normalize during development
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craniofacial
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• hypoplastic at E10.5
• however, arteries normalize during development
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embryo
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• hypoplastic at E10.5
• however, arteries normalize during development
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
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mortality/aging
embryo
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• 45% of embryos have either undetectable fourth arch arteries or reduced size of fourth arch arteries
(J:57757)
• however, mice do not exhibit craniofacial defects such as cleft palate
(J:57757)
• abnormal in all embryos at E10.5
(J:67409)
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• undetectable fourth arch arteries in some embryos
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cardiovascular system
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• 45% of embryos have either undetectable fourth arch arteries or reduced size of fourth arch arteries
(J:57757)
• however, mice do not exhibit craniofacial defects such as cleft palate
(J:57757)
• abnormal in all embryos at E10.5
(J:67409)
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• undetectable fourth arch arteries in some embryos
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• aberrant origin of the right subclavian artery from the pulmonary trunk
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• most frequent abnormality is a retroesophageal right subclavian artery, which originates from the descending aorta, dorsal to the emergence of the left subclavian artery
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• some embryos have interrupted aortic arch type B (IAA-B)
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• 26% of E18.5 embryos and 18% of adults exhibit cardiovascular abnormalities in various combinations, however none exhibit persistent truncus arteriosus or tetralogy of Fallot
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• some embryos have a ventricular septal defect
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• infundibular pulmonary stenosis in some embryos
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craniofacial
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• 45% of embryos have either undetectable fourth arch arteries or reduced size of fourth arch arteries
(J:57757)
• however, mice do not exhibit craniofacial defects such as cleft palate
(J:57757)
• abnormal in all embryos at E10.5
(J:67409)
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• undetectable fourth arch arteries in some embryos
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immune system
N |
• normal numbers of B and T cells at 2-6 months of age and a normal thymus
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
Tbx1tm1Bld mutation
(1 available);
any
Tbx1 mutation
(34 available)
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embryo
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• the second arch arteries are reduced in size
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cardiovascular system
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• dorsal aortae originate directly from the aortic sac
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• the second arch arteries are reduced in size
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craniofacial
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• the second arch arteries are reduced in size
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
Dp(16Dgcr14-Sept5)3Bld mutation
(1 available);
any
Dp(16Dgcr14-Sept5)3Bld mutation
(1 available)
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cardiovascular system
N |
• no cardiovascular defects similar to those in other deletions are observed
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Sept5)3Bld mutation
(1 available);
any
Del(16Es2el-Sept5)3Bld mutation
(1 available)
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
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cardiovascular system
N |
• no cardiovascular defects similar to those in other deletions are observed
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Es2el-Ufd1l)217Bld mutation
(1 available);
any
Del(16Es2el-Ufd1l)217Bld mutation
(1 available)
Tbx1tm1Bld mutation
(1 available);
any
Tbx1 mutation
(34 available)
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cardiovascular system
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• identical phenotype to Tbx1tm1Bld homozygotes
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• identical phenotype to Tbx1tm1Bld homozygotes
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• identical phenotype to Tbx1tm1Bld homozygotes
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craniofacial
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• identical phenotype to Tbx1tm1Bld homozygotes
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• identical phenotype to Tbx1tm1Bld homozygotes
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• identical phenotype to Tbx1tm1Bld homozygotes
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• identical phenotype to Tbx1tm1Bld homozygotes
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embryo
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• identical phenotype to Tbx1tm1Bld homozygotes
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• identical phenotype to Tbx1tm1Bld homozygotes
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• identical phenotype to Tbx1tm1Bld homozygotes
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• identical phenotype to Tbx1tm1Bld homozygotes
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