Phenotypes associated with this allele

• Allele Symbol: Angptl3^tm1Kfuj
• Allele Name: targeted mutation 1, Kazunori Fujimoto
• Allele ID: MGI:3623491
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Angptl3^tm1Kfuj/Angptl3^tm1Kfuj	B6.129S1-Angptl3^tm1Kfuj	MGI:3623681

Genotype
MGI:3623681

hm1

• Allelic Composition: Angptl3^tm1Kfuj/Angptl3^tm1Kfuj
• Genetic Background: B6.129S1-Angptl3^tm1Kfuj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:107479 )

• significantly decreased

decreased circulating VLDL cholesterol level ( J:107479 )

• VLDL and chylomicron levels particularly reduced

decreased circulating free fatty acids level ( J:107479 )

• significantly decreased

decreased circulating triglyceride level ( J:107479 )

• significantly decreased

• increased clearance of plasma triglycerides

• lipoprotein lipase activity increased 1.57X

liver/biliary system

increased liver weight ( J:107479 )

• liver weights increased but not significantly

• no difference in hepatocyte lipid content

abnormal liver physiology ( J:107479 )

• slight but insignificantly decreased hepatic triglyceride secretion rate

adipose tissue

decreased epididymal fat pad weight ( J:107479 )

• weight of epididymal adipose tissue is reduced, particularly on a high fat and high calory diet

• adipocyte size is unchanged

growth/size/body

increased liver weight ( J:107479 )

• liver weights increased but not significantly

• no difference in hepatocyte lipid content