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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crlf2tm1Wjl
targeted mutation 1, Warren J Leonard
MGI:3623417
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crlf2tm1Wjl/Crlf2tm1Wjl involves: 129 * C57BL/6 MGI:3624430
hm2
 		Crlf2tm1Wjl/Crlf2tm1Wjl involves: BALB/c MGI:3624450
hm3
 		Crlf2tm1Wjl/Crlf2tm1Wjl Not Specified MGI:5294923
cx4
 		Tg(DO11.10)10Dlo/0
Crlf2tm1Wjl/Crlf2tm1Wjl 		involves: 129 * BALB/c * C3H * C57BL/6 MGI:3624449
cx5
 		Il2rgtm1Wjl/Y
Crlf2tm1Wjl/Crlf2tm1Wjl 		involves: 129S4/SvJae * C57BL/6 MGI:3624431


Genotype
MGI:3624430
hm1
Allelic
Composition		 Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal lymphopoiesis ( J:108209 )
• after sublethal irradiation, mutants do not recover thymic or splenic cellularity after 4 weeks, while controls show high recovery of cellularity after 4 weeks
decreased B cell number ( J:108209 )
• spleens of irradiated mutants have reduced numbers of B220+ CD19+ B cells compared to wild-type controls, indicating less efficient B cell recovery
decreased single-positive T cell number ( J:108209 )
• after irradiation, CD4+ and CD8+ subpopulations in the thymus and spleen are lower in mutants compared to wild-type littermates

immune system
abnormal lymphopoiesis ( J:108209 )
• after sublethal irradiation, mutants do not recover thymic or splenic cellularity after 4 weeks, while controls show high recovery of cellularity after 4 weeks
decreased B cell number ( J:108209 )
• spleens of irradiated mutants have reduced numbers of B220+ CD19+ B cells compared to wild-type controls, indicating less efficient B cell recovery
decreased single-positive T cell number ( J:108209 )
• after irradiation, CD4+ and CD8+ subpopulations in the thymus and spleen are lower in mutants compared to wild-type littermates




Genotype
MGI:3624450
hm2
Allelic
Composition		 Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell proliferation ( J:107431 )
• CD4+ T cells isolated from OVA-immunized mice show less proliferation in response to secondary antigen exposure than wild-type T cells
decreased splenocyte proliferation ( J:107431 )
• splenocytes from null mice have a lower proliferative response to secondary exposure to OVA than do wild-type
decreased immunoglobulin level ( J:107431 )
• knockouts have lower levels of IgE and IgG2 than wild-type mice
abnormal cytokine secretion ( J:107431 )
• knockouts sensitized to OVA and challenged with OVA do not show increased levels of cytokines like control mice do
lung inflammation ( J:107431 )
• knockout mice immunized 2x with OVA have much fewer cellular infiltrates and very little goblet cell hyperplasia in the bronchi when challenged with OVA compared wild-type controls challenged with OVA

respiratory system
lung inflammation ( J:107431 )
• knockout mice immunized 2x with OVA have much fewer cellular infiltrates and very little goblet cell hyperplasia in the bronchi when challenged with OVA compared wild-type controls challenged with OVA

hematopoietic system
abnormal T cell proliferation ( J:107431 )
• CD4+ T cells isolated from OVA-immunized mice show less proliferation in response to secondary antigen exposure than wild-type T cells
decreased splenocyte proliferation ( J:107431 )
• splenocytes from null mice have a lower proliferative response to secondary exposure to OVA than do wild-type
decreased immunoglobulin level ( J:107431 )
• knockouts have lower levels of IgE and IgG2 than wild-type mice

cellular
abnormal T cell proliferation ( J:107431 )
• CD4+ T cells isolated from OVA-immunized mice show less proliferation in response to secondary antigen exposure than wild-type T cells
decreased splenocyte proliferation ( J:107431 )
• splenocytes from null mice have a lower proliferative response to secondary exposure to OVA than do wild-type




Genotype
MGI:5294923
hm3
Allelic
Composition		 Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
colitis ( J:175844 )
• DSS-treated mice fail to recover from induced colitis compared with similarly treated wild-type mice
• mice reconstituted with wild-type bone marrow exhibit recovery from DSS-induced colitis
• however, mice exhibit normal onset, severity, and sensitivity to DSS-induced colitis

immune system
colitis ( J:175844 )
• DSS-treated mice fail to recover from induced colitis compared with similarly treated wild-type mice
• mice reconstituted with wild-type bone marrow exhibit recovery from DSS-induced colitis
• however, mice exhibit normal onset, severity, and sensitivity to DSS-induced colitis

homeostasis/metabolism




Genotype
MGI:3624449
cx4
Allelic
Composition		 Tg(DO11.10)10Dlo/0
Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background		 involves: 129 * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (21 available)
Tg(DO11.10)10Dlo mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased inflammatory response ( J:107431 )
• when transgenic mutant mice are injected with OVA, there is little induction of CD69+ on CD4+ T cells; CD69+ expression is significantly induced on CD 4+ cells of nontransgenic Tpte2-deficient controls




Genotype
MGI:3624431
cx5
Allelic
Composition		 Il2rgtm1Wjl/Y
Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (21 available)
Il2rgtm1Wjl mutation (77 available); any Il2rg mutation (168 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

hematopoietic system
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

endocrine/exocrine glands
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory