All Phenotypes Disc1<tm1Kara> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Disc1^tm1Kara
targeted mutation 1, Maria Karayiorgou
MGI:3623218

Summary

2 genotypes

Allelic Composition	Disc1^tm1Kara/Disc1^tm1Kara
Genetic Background	B6.129S6-Disc1^tm1Kara

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disc1^tm1Kara mutation (0 available); any Disc1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

• working memory measured by a delayed non-match to place task was impaired compared with wild-type litter-mate controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:107244

Allelic Composition	Disc1^tm1Kara/Disc1⁺
Genetic Background	B6.129S6-Disc1^tm1Kara

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disc1^tm1Kara mutation (0 available); any Disc1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

• working memory measured by a delayed non-match to place task was impaired compared with wild-type litter-mate controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:107244

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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